MSN4/YKL062W Protein Information

Standard Name	Msn4p 1
Systematic Name	Ykl062wp
ORF Classification	Verified
Description	Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication (2, 3, 4)
Name Description	Multicopy suppressor of SNF1 mutation 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	630
Molecular Weight (Da)	69,722
Isoelectric Point (pI)	7.23

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Msn4p (InterPro)
Physical Interactions	There are 23 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F624 \| P33749 MIPS: YKL062W NCBI: 349593 \| 433646 \| 462626 \| 486083 \| 6322788 \| NP_012861.1 GenBank/EMBL/DDBJ: DAA09095.1 \| L08839 \| X75781 \| Z28062

Amino Acid Sequence (or in FASTA format)
1 MLVFGPNSSF VRHANKKQED SSIMNEPNGL MDPVLSTTNV SATSSNDNSA 51 NNSISSPEYT FGQFSMDSPH RTDATNTPIL TATTNTTANN SLMNLKDTAS 101 LATNWKWKNS NNAQFVNDGE KQSSNANGKK NGGDKIYSSV ATPQALNDEL 151 KNLEQLEKVF SPMNPINDSH FNENIELSPH QHATSPKTNL LEAEPSIYSN 201 LFLDARLPNN ANSTTGLNDN DYNLDDTNND NTNSMQSILE DFVSSEEALK 251 FMPDAGRDAR RYSEVVTSSF PSMTDSRNSI SHSIEFWNLN HKNSSNSKPT 301 QQIIPEGTAT TERRGSTISP TTTINNSNPN FKLLDHDVSQ ALSGYSMDFS 351 KDSGITKPKS ISSSLNRISH SSSTTRQQRA SLPLIHDIES FANDSVMANP 401 LSDSASFLSE ENEDDAFGAL NYNSLDATTM SAFDNNVDPF NILKSSPAQD 451 QQFIKPSMML SDNASAAAKL ATSGVDNITP TPAFQRRSYD ISMNSSFKIL 501 PTSQAHHAAQ HHQQQPTKQA TVSPNTRRRK SSSVTLSPTI SHNNNNGKVP 551 VQPRKRKSIT TIDPNNYDKN KPFKCKDCEK AFRRSEHLKR HIRSVHSTER 601 PFACMFCEKK FSRSDNLSQH LKTHKKHGDF *

Amino Acid Sequence (or in FASTA format)

       1  MLVFGPNSSF VRHANKKQED SSIMNEPNGL MDPVLSTTNV SATSSNDNSA
      51  NNSISSPEYT FGQFSMDSPH RTDATNTPIL TATTNTTANN SLMNLKDTAS
     101  LATNWKWKNS NNAQFVNDGE KQSSNANGKK NGGDKIYSSV ATPQALNDEL
     151  KNLEQLEKVF SPMNPINDSH FNENIELSPH QHATSPKTNL LEAEPSIYSN
     201  LFLDARLPNN ANSTTGLNDN DYNLDDTNND NTNSMQSILE DFVSSEEALK
     251  FMPDAGRDAR RYSEVVTSSF PSMTDSRNSI SHSIEFWNLN HKNSSNSKPT
     301  QQIIPEGTAT TERRGSTISP TTTINNSNPN FKLLDHDVSQ ALSGYSMDFS
     351  KDSGITKPKS ISSSLNRISH SSSTTRQQRA SLPLIHDIES FANDSVMANP
     401  LSDSASFLSE ENEDDAFGAL NYNSLDATTM SAFDNNVDPF NILKSSPAQD
     451  QQFIKPSMML SDNASAAAKL ATSGVDNITP TPAFQRRSYD ISMNSSFKIL
     501  PTSQAHHAAQ HHQQQPTKQA TVSPNTRRRK SSSVTLSPTI SHNNNNGKVP
     551  VQPRKRKSIT TIDPNNYDKN KPFKCKDCEK AFRRSEHLKR HIRSVHSTER
     601  PFACMFCEKK FSRSDNLSQH LKTHKKHGDF *

external links for Msn4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Msn4p

1)	Estruch F and Carlson M (1993) Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol Cell Biol 13(7):3872-81
2)	Martinez-Pastor MT, et al. (1996) The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J 15(9):2227-35
3)	Gorner W, et al. (1998) Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev 12(4):586-97
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61