SFK1/YKL051W Protein Information

Standard Name	Sfk1p 1
Systematic Name	Ykl051wp
ORF Classification	Verified
Description	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane (1)
Name Description	Suppressor of Four Kinase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	353
Molecular Weight (Da)	40,462
Isoelectric Point (pI)	7.28

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sfk1p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 52 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B6CB \| P35735 MIPS: YKL051W NCBI: 433650 \| 486070 \| 549678 \| 6322800 \| NP_012873.1 \| NM_001179617.1 GenBank/EMBL/DDBJ: DAA09106.1 \| X75781 \| Z28051

Amino Acid Sequence (or in FASTA format)
1 MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP 51 VYISDIGATN LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP 101 SISDSTSYAE KLHSGKYLMP PYYTKDERNL IFAAFVLGSI GELALLFSSI 151 FSTALYHRVH IAMVSVFVVF MFLSTCCLIA EYFLMGRHYA SVHPLASPHF 201 NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV IWLTLAVVWA 251 ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE 301 SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ 351 VVV*

Amino Acid Sequence (or in FASTA format)

       1  MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP
      51  VYISDIGATN LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP
     101  SISDSTSYAE KLHSGKYLMP PYYTKDERNL IFAAFVLGSI GELALLFSSI
     151  FSTALYHRVH IAMVSVFVVF MFLSTCCLIA EYFLMGRHYA SVHPLASPHF
     201  NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV IWLTLAVVWA
     251  ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE
     301  SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ
     351  VVV*

external links for Sfk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Sfk1p

1)	Audhya A and Emr SD (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell 2(5):593-605