ELM1/YKL048C Protein Information Help

Standard Name Elm1p
Systematic Name Ykl048cp
Alias Ldb9p
ORF Classification Verified
Description Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring (1, 2, 3, 4, 5)
Name Description ELongated Morphology 6
Experimental Data
Molecules/cell 149 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 640
Molecular Weight (Da) 72,149
Isoelectric Point (pI) 8.04

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Elm1p (InterPro)
Physical Interactions There are 35 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000129E69 | P32801
MIPS: YKL048C
NCBI: 171452 | 486147 | 544240 | 6322803 | NP_012876.1
GenBank/EMBL/DDBJ: DAA09109.1 | M81258 | X71621 | Z28048
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSPRQLIPTL IPEWAPLSQQ SCIREDELDS PPITPTSQTS SFGSSFSQQK
      51  PTYSTIIGEN IHTILDEIRP YVKKITVSDQ DKKTINQYTL GVSAGSGQFG
     101  YVRKAYSSTL GKVVAVKIIP KKPWNAQQYS VNQVMRQIQL WKSKGKITTN
     151  MSGNEAMRLM NIEKCRWEIF AASRLRNNVH IVRLIECLDS PFSESIWIVT
     201  NWCSLGELQW KRDDDEDILP QWKKIVISNC SVSTFAKKIL EDMTKGLEYL
     251  HSQGCIHRDI KPSNILLDEE EKVAKLSDFG SCIFTPQSLP FSDANFEDCF
     301  QRELNKIVGT PAFIAPELCH LGNSKRDFVT DGFKLDIWSL GVTLYCLLYN
     351  ELPFFGENEF ETYHKIIEVS LSSKINGNTL NDLVIKRLLE KDVTLRISIQ
     401  DLVKVLSRDQ PIDSRNHSQI SSSSVNPVRN EGPVRRFFGR LLTKKGKKKT
     451  SGKGKDKVLV SATSKVTPSI HIDEEPDKEC FSTTVLRSSP DSSDYCSSLG
     501  EEAIQVTDFL DTFCRSNESL PNLTVNNDKQ NSDMKTDRSE SSSHSSLKIP
     551  TPIKAMIRLK SSPKENGNRT HINCSQDKPS SPLMDRTVGK RTVNNSGARK
     601  LAHSSNILNF KAYINSEDSD IRETVEDVKT YLNFADNGQI *

external links for Elm1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Elm1p
1) Bouquin N, et al.  (2000) Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. J Cell Sci 113 ( Pt 8)():1435-45
2) Garrett JM  (1997) The control of morphogenesis in Saccharomyces cerevisiae by Elm1 kinase is responsive to RAS/cAMP pathway activity and tryptophan availability. Mol Microbiol 26(4):809-20
3) Sreenivasan A and Kellogg D  (1999) The elm1 kinase functions in a mitotic signaling network in budding yeast. Mol Cell Biol 19(12):7983-94
4) Koehler CM and Myers AM  (1997) Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae. FEBS Lett 408(1):109-14
5) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
6) Blacketer MJ, et al.  (1993) Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A. Mol Cell Biol 13(9):5567-81
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41