PHD1/YKL043W Protein Information

Standard Name	Phd1p 1
Systematic Name	Ykl043wp
ORF Classification	Verified
Description	Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	PseudoHyphal Determinant 1

Experimental Data
Molecules/cell	1420 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	366
Molecular Weight (Da)	40,646
Isoelectric Point (pI)	9.7

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Phd1p (InterPro)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000131928 \| P36093 MIPS: YKL043W NCBI: 451850 \| 45269737 \| 486056 \| 549671 \| 63028949 \| 63028951 \| 63028953 \| 63028955 \| 63028957 \| 63028959 \| 63028961 \| 63028963 \| 63028965 \| 63028967 \| 6322808 \| 666097 \| NP_012881.1 GenBank/EMBL/DDBJ: DAA09113.1 \| AY557923 \| AY949939 \| AY949940 \| AY949941 \| AY949942 \| AY949943 \| AY949944 \| AY949945 \| AY949946 \| AY949947 \| AY949948 \| U05241 \| X71621 \| Z28043

Amino Acid Sequence (or in FASTA format)
1 MYHVPEMRLH YPLVNTQSNA AITPTRSYDN TLPSFNELSH QSTINLPFVQ 51 RETPNAYANV AQLATSPTQA KSGYYCRYYA VPFPTYPQQP QSPYQQAVLP 101 YATIPNSNFQ PSSFPVMAVM PPEVQFDGSF LNTLHPHTEL PPIIQNTNDT 151 SVARPNNLKS IAAASPTVTA TTRTPGVSST SVLKPRVITT MWEDENTICY 201 QVEANGISVV RRADNNMING TKLLNVTKMT RGRRDGILRS EKVREVVKIG 251 SMHLKGVWIP FERAYILAQR EQILDHLYPL FVKDIESIVD ARKPSNKASL 301 TPKSSPAPIK QEPSDNKHEI ATEIKPKSID ALSNGASTQG AGELPHLKIN 351 HIDTEAQTSR AKNELS*

Amino Acid Sequence (or in FASTA format)

       1  MYHVPEMRLH YPLVNTQSNA AITPTRSYDN TLPSFNELSH QSTINLPFVQ
      51  RETPNAYANV AQLATSPTQA KSGYYCRYYA VPFPTYPQQP QSPYQQAVLP
     101  YATIPNSNFQ PSSFPVMAVM PPEVQFDGSF LNTLHPHTEL PPIIQNTNDT
     151  SVARPNNLKS IAAASPTVTA TTRTPGVSST SVLKPRVITT MWEDENTICY
     201  QVEANGISVV RRADNNMING TKLLNVTKMT RGRRDGILRS EKVREVVKIG
     251  SMHLKGVWIP FERAYILAQR EQILDHLYPL FVKDIESIVD ARKPSNKASL
     301  TPKSSPAPIK QEPSDNKHEI ATEIKPKSID ALSNGASTQG AGELPHLKIN
     351  HIDTEAQTSR AKNELS*

external links for Phd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Phd1p

1)	Gimeno CJ and Fink GR (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
2)	Pan X and Heitman J (2000) Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol 20(22):8364-72
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Hanlon SE, et al. (2011) The Stress Response Factors Yap6, Cin5, Phd1, and Skn7 Direct Targeting of the Conserved Co-Repressor Tup1-Ssn6 in S. cerevisiae. PLoS One 6(4):e19060
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41