RGT1/YKL038W Protein Information Help

Standard Name Rgt1p
Systematic Name Ykl038wp
ORF Classification Verified
Description Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication (1, 2, 3)
Name Description Restores Glucose Transport 4
Experimental Data
Molecules/cell 195 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,170
Molecular Weight (Da) 128,239
Isoelectric Point (pI) 7.88

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rgt1p (InterPro)
Physical Interactions There are 29 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B6C2 | P32862
MIPS: YKL038W
NCBI: 398364609 | 418572 | 4792 | 486046 | NP_012886.3
GenBank/EMBL/DDBJ: DAA09118.1 | X69584 | Z28038
Amino Acid Sequence (or in FASTA format)
 
       1  MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC
      51  RKKKIKCDYK DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT
     101  NEIQDHNNSR SYNTFDNSNN TLNNNTGNSG DNGINSNTVP STPSRSNSVL
     151  LPPLTQYIPQ AGGIPPSFQN PAIQSTMPAG NIGQQQFWKV PYHEFQHQRK
     201  GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG NANGSVTGSG
     251  SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG
     301  QPQLPPPQQQ SQPQAHQQKL QQGQNLYSYS QFSQQQPYNP SISSFGQFAA
     351  NGFHSRQGSV ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS
     401  ELDGNKRRQS APVSVTLSTD RLNGNENNNG EINNNNGSNN SGSSKDTSQH
     451  SQESVTTPAA LEASSPGSTP QRSTKKRRKS YVSKKTKPKR DSSISITSKD
     501  SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK TTLTSDLLLV
     551  NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP
     601  SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI
     651  VDIHPKFREN NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI
     701  FNEFKLYKLL LFPEPDINDV KPPVDEEVST GNGNTKTSEF EIGSESAGHM
     751  NPSNSPNSMD ENISHYSVLF KRLYVLLSVF DSLQSCAFGG PKLLNISIQG
     801  STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT RNRISMNGNR
     851  KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA
     901  GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP
     951  PANNPTVQEG PSAMGSSPVA GNLSAAPPSE GNPDFYKKLL GLKQDTGTIL
    1001  SDLCRGIISP FAIAILHEVY NITELVKQMP TSLISIMMTA TTTQNTQDTK
    1051  KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK IFEHELNKPI MSLTGGLSST
    1101  TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA AEEPRLENVA
    1151  LENFVSIGWK LLDDSELGWY *

external links for Rgt1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rgt1p
1) Ozcan S, et al.  (1996) Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol Cell Biol 16(11):6419-26
2) Kim JH, et al.  (2003) Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Mol Cell Biol 23(15):5208-16
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Marshall-Carlson L, et al.  (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics 128(3):505-12
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41