TTI1/YKL033W Protein Information Help

Standard Name Tti1p 1
Systematic Name Ykl033wp
ORF Classification Verified
Description Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies (1, 2, 3, 4)
Name Description Two Tel2-Interacting protein 1
Experimental Data
Molecules/cell 721 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,038
Molecular Weight (Da) 118,888
Isoelectric Point (pI) 4.87

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tti1p (InterPro)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B6BB | P36097
MIPS: YKL033W
NCBI: 486036 | 549666 | 6322819 | NP_012892.1
GenBank/EMBL/DDBJ: DAA09123.1 | X71622 | Z28033
Amino Acid Sequence (or in FASTA format)
 
       1  MNSDTNAFKD IRISCVELSR IAFLPTESFD PNSLTLLACL KKVEEKLSAY
      51  EDDSLSPKFA DYVFVPIASL LKQPALGESQ TEYVLLIIFH LLRTCWSSNG
     101  KFSEQLGQQL FPLITFLVSS DKDNQKLITR SDEFKYAGCL VLHQFFKSVR
     151  SQRYHKEFFS NSKPNLLPAL GHSVTILLKI LEQSPQNNEL QFKALASLEV
     201  LFQDIISDGE MLSFILPGNV SVFAKILTKP GRQIHYKVCV RTLEVLAKLL
     251  VLVYDDFSLD IKVNKLTDIR ELSDTKLKHE INQSFMFNGP IVLLRTDGKT
     301  HRDTSWLTAT SGQINIALEA FIPKLLKRNN ESIDEALATF VSILLTRCEN
     351  SLNNCEKVLV STLVHLERDP MSKLPSHLVK LKEVVNEDLH KLSDIIRFEN
     401  ADRLSSLSFA ITILEKNNER DTMINEVVRC LFESLNESIE PPSLINHKER
     451  IIEQSSQLTT TVNFENLEST NALIALPRLS EDMSLKLKKF TYHMGSLLLE
     501  RHILNDVVTE LISEQVDSPR TQKIVALWLS TNFIKAMEKQ PKEEEVYLQF
     551  ESDANYSSSM VEEVCLIVLE FCNELSQDIS MEIEGKGIKK SDEFAVCTVL
     601  FSIETICAVM REEFQPELID YIYTVVDALA SPSEAIRYVS QSCALRIADT
     651  LYHGSIPNMI LSNVDYLVES ISSRLNSGMT ERVSQILMVI CQLAGYETIE
     701  NFKDVIETIF KLLDYYHGYS DLCLQFFQLF KIIILEMKKK YINDDEMILK
     751  IANQHISQST FSPWGMTDFQ QVLNILDKET QVKDDITDEN DVDFLKDDNE
     801  PSNFQEYFDS KLREPDSDDD EEEREEEVEG SSKEYTDQWT SPIPSDSYKI
     851  LLQILGYGER LLTHPSKRLR VQILIVMRLI FPLLSTQHNL LIREVASTWD
     901  SIIQCVLCSD YSIVQPACSC VEQMIKYSGD FVAKRFIELW QKLCQDSFIL
     951  KELRIDPTVH NHEKKSISKH VKFPPVTENA LVSMVHMVLE GVKITEYLIS
    1001  EAVLEQIIYC CIQVVPVEKI SSMSLIVGDI VWKIRNIN*

external links for Tti1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Tti1p
1) Shevchenko A, et al.  (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9(11):R167
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
4) Stirling PC, et al.  (2011) The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components. PLoS Genet 7(4):e1002057
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41