GPX1/YKL026C Protein Information Help

Standard Name Gpx1p 1
Systematic Name Ykl026cp
ORF Classification Verified
Description Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication (1, 2, 3)
Name Description Glutathione PeroXidase 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 167
Molecular Weight (Da) 19,484
Isoelectric Point (pI) 8.45

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gpx1p (InterPro)
Physical Interactions There are 2 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012BBF4 | P36014
MIPS: YKL026C
NCBI: 398364659 | 45269681 | 486023 | 544438 | NP_012899.3
GenBank/EMBL/DDBJ: DAA09128.1 | AY557895 | Z28026
External Classifications EC: 1.11.1.9 [Glutathione peroxidase]
Amino Acid Sequence (or in FASTA format)
 
       1  MQEFYSFSPI DENGNPFPFN SLRNKVVLIV NVASHCAFTP QYKELEYLYE
      51  KYKSHGLVIV AFPCGQFGNQ EFEKDKEINK FCQDKYGVTF PILHKIRCNG
     101  QKQDPVYKFL KNSVSGKSGI KMIKWNFEKF VVDRNGKVVK RFSCMTRPLE
     151  LCPIIEELLN QPPEEQI*

external links for Gpx1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Gpx1p
1) Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9
2) Avery AM and Avery SV  (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61