PAN3/YKL025C Protein Information Help

Standard Name Pan3p 1
Systematic Name Ykl025cp
Alias Ecm35p
ORF Classification Verified
Description Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes (1, 2, 3)
Name Description Poly(A) Nuclease 1
Experimental Data
Molecules/cell 1600 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 679
Molecular Weight (Da) 76,454
Isoelectric Point (pI) 6.38

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pan3p (InterPro)
Physical Interactions There are 23 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000131265 | P36102
MIPS: YKL025C
NCBI: 486021 | 549662 | 6322827 | NP_012900.1 | NM_001179591.1
GenBank/EMBL/DDBJ: DAA09129.1 | Z28025
Amino Acid Sequence (or in FASTA format)
 
       1  MDKINPDWAK DIPCRNITIY GYCKKEKEGC PFKHSDNTTA TTINDVPPPI
      51  DVGEATTPTM TSVPKFNAKV SASFTPMTVG SDSLTTVTNT TSAATNATGN
     101  IAMAATSATA STVNPMINPI VNSSLVNNNN NNSNISISIP TTASSSNYDP
     151  FNAPIFTPSS TSSIHTNANA HSFPFPSIAN SGGININATD DNSNNMSMAN
     201  NVPPPMQPPP IESSNLKYPR IYPPPHSLLQ YHLYAPEQPS SLKSLLKPNE
     251  RSADQLFIPN NIREDLTKKN LSILQVFPSS GKVIPSIVQD YFNLVPLNFN
     301  NNDFLNKTTL FKVFSNYDGK AYVLKRLPNI DKSMNPNKIS KIYQIWSKIN
     351  CTNLIKFRDI FQTTKFGDLS ICLVFDYYPN SLSLYDYHFV NFPKFPITNN
     401  YLWIYLVQLT NVINSIHSQN LSIGNTLNWR KVLITGDPGR IKLSHCNFMD
     451  LLFNDDTDTV VSSGGSTIEG QQQLDYKYLG ELLFNLSINI ENSNNNTAPK
     501  EYRLEEITPQ SIDDMRQIDD KFKDVLKYLI SDNGDSKKSI HDLTSHFYDK
     551  MFMVLESSQT YTEYMESVLS RELENGRLFR LVNKLNCIFG RIESRIDINW
     601  SESGTKFPII LFYDYVFHQV DSNGKPIMDL THVLRCLNKL DAGIQEKLML
     651  VTPDELNCII ISYKELKDLI ESTFRSITQ*

external links for Pan3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Pan3p
1) Brown CE, et al.  (1996) PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5744-53
2) Brown CE and Sachs AB  (1998) Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation. Mol Cell Biol 18(11):6548-59
3) Hammet A, et al.  (2002) Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. J Biol Chem 277(25):22469-74
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41