URA6/YKL024C Protein Information

Standard Name	Ura6p
Systematic Name	Ykl024cp
Alias	Soc8p
ORF Classification	Verified
Description	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) (1, 2, 3, 4)
Name Description	URAcil requiring 4, 5

Experimental Data
Molecules/cell	1500 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	204
Molecular Weight (Da)	22,933
Isoelectric Point (pI)	6.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ura6p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000137C32 \| P15700 MIPS: YKL024C NCBI: 137024 \| 157834086 \| 157834087 \| 173138 \| 173150 \| 398364671 \| 45270038 \| 486019 \| NP_012901.3 GenBank/EMBL/DDBJ: DAA09130.1 \| AY558074 \| M31455 \| M69295 \| Z28024
External Classifications	EC: 2.7.4.14 [UMP/CMP kinase]

Amino Acid Sequence (or in FASTA format)
1 MTAATTSQPA FSPDQVSVIF VLGGPGAGKG TQCEKLVKDY SFVHLSAGDL 51 LRAEQGRAGS QYGELIKNCI KEGQIVPQEI TLALLRNAIS DNVKANKHKF 101 LIDGFPRKMD QAISFERDIV ESKFILFFDC PEDIMLERLL ERGKTSGRSD 151 DNIESIKKRF NTFKETSMPV IEYFETKSKV VRVRCDRSVE DVYKDVQDAI 201 RDSL*

Amino Acid Sequence (or in FASTA format)

       1  MTAATTSQPA FSPDQVSVIF VLGGPGAGKG TQCEKLVKDY SFVHLSAGDL
      51  LRAEQGRAGS QYGELIKNCI KEGQIVPQEI TLALLRNAIS DNVKANKHKF
     101  LIDGFPRKMD QAISFERDIV ESKFILFFDC PEDIMLERLL ERGKTSGRSD
     151  DNIESIKKRF NTFKETSMPV IEYFETKSKV VRVRCDRSVE DVYKDVQDAI
     201  RDSL*

external links for Ura6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ura6p

1)	Jong A, et al. (1993) Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase. Arch Biochem Biophys 304(1):197-204
2)	Ma JJ, et al. (1990) Purification and characterization of Saccharomyces cerevisiae uridine monophosphate kinase. J Biol Chem 265(31):19122-7
3)	Choi WJ, et al. (1989) The Saccharomyces cerevisiae SOC8-1 gene and its relationship to a nucleotide kinase. J Biol Chem 264(26):15593-9
4)	Liljelund P and Lacroute F (1986) Genetic characterization and isolation of the Saccharomyces cerevisiae gene coding for uridine monophosphokinase. Mol Gen Genet 205(1):74-81
5)	Liljelund P, et al. (1989) Primary structure of the S. cerevisiae gene encoding uridine monophosphokinase. Biochem Biophys Res Commun 165(1):464-73
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41