CDC16/YKL022C Protein Information Help

Standard Name Cdc16p
Systematic Name Ykl022cp
ORF Classification Verified
Description Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation (1)
Name Description Cell Division Cycle 2
Experimental Data
Molecules/cell 2750 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 840
Molecular Weight (Da) 94,991
Isoelectric Point (pI) 6.74

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cdc16p (InterPro)
Physical Interactions There are 206 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052EF9 | P09798
MIPS: YKL022C
NCBI: 115908 | 3478 | 486015 | 6322830 | NP_012903.1
GenBank/EMBL/DDBJ: DAA09133.1 | X06165 | Z28022
Amino Acid Sequence (or in FASTA format)
 
       1  MKFCLYCCHC YIVICGKATH YYKSSKATSN LKSSNRVLMR NPMSPSEQHS
      51  QHNSTLAASP FVSNVSAART QQSLPTDAQN DRLQQPWNRT NTATSPYQSL
     101  ANSPLIQKLQ ANIMTPHQPS ANSNSNSNSI TGNVVNDNNL LASMSKNSMF
     151  GSTIPSTLRK VSLQREYKDS VDGVVRDEDN DEDVHNNGDA AANANNDRES
     201  KLGHNGPLTT TTLTTTTTAT QLDVSELSAI ERLRLWRFDA LMQHMYRTAE
     251  YIADKVYNIS NDPDDAFWLG QVYYNNNQYV RAVELITRNN LDGVNILCRY
     301  LLGLSFVKLQ RFDDALDVIG EYNPFSEDPS TTAANTMSNN GNNSNTSQPV
     351  TDGGIKMESS LCFLRGKIYF AQNNFNKARD AFREAILVDI KNFEAFEMLL
     401  SKNLLTPQEE WDLFDSLDFK EFGEDKEIMK NLYKINLSKY INTEDITKSN
     451  EILAKDYKLA DNVDVVRSKV DICYTQCKFN ECLELCETVL ENDEFNTNIL
     501  PAYIGCLYEL SNKNKLFLLS HRLAETFPKS AITWFSVATY YMSLDRISEA
     551  QKYYSKSSIL DPSFAAAWLG FAHTYALEGE QDQALTAYST ASRFFPGMHL
     601  PKLFLGMQFM AMNSLNLAES YFVLAYDICP NDPLVLNEMG VMYFKKNEFV
     651  KAKKYLKKAL EVVKDLDPSS RTTISIQLNL GHTYRKLNEN EIAIKCFRCV
     701  LEKNDKNSEI HCSLGYLYLK TKKLQKAIDH LHKSLYLKPN NSSATALLKN
     751  ALELNVTLSL DASHPLIDKS NLMSQASKDK ASLNKKRSSL TYDPVNMAKR
     801  LRTQKEIFDQ NNKALRKGGH DSKTGSNNAD DDFDADMELE *

external links for Cdc16p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cdc16p
1) Zachariae W and Nasmyth K  (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58
2) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41