MAK11/YKL021C Protein Information

Standard Name	Mak11p
Systematic Name	Ykl021cp
ORF Classification	Verified
Description	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats (1, 2)
Name Description	MAintenance of Killer 3

Experimental Data
Molecules/cell	3730 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	468
Molecular Weight (Da)	53,672
Isoelectric Point (pI)	8.58

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mak11p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 54 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F17F \| P20484 MIPS: YKL021C NCBI: 127111 \| 171877 \| 398364695 \| 486013 \| NP_012904.3 \| NM_001179587.3 GenBank/EMBL/DDBJ: DAA09134.1 \| J03506 \| Z28021

Amino Acid Sequence (or in FASTA format)
1 MLLNTTYTVF IFFLLRIIKF KIKAENFLEH EKLKTHGTSS RKDPKGQVKN 51 SCRKMSAIGD KNQFRIIVGS YEHNILCLSL DIPNQKENDA AKTPHFMPIF 101 HFQAHSLSIK CLAVSRRYLV SGSNDEHIRI YDLQKRKELG TLLSHQGSIT 151 ALQFSHPASS SEDAAVSKGS KNSKWLLSAS EDHKIMVWRV KDWETVGTLK 201 GHTARVNDVD IHPTNRIAIS VSDDHSIRLW NLMTLRNAAV LKLRKYNTNG 251 TCVRWLGAKG DYFAVGLRDR VLIYETGSAK VFKEIVFQRK TLMHIETHIL 301 PFDNKEYLSV GISDGNVHFY PCEELFEKVE ENEKQEDDDD KEDISPAFSL 351 LGHTNRIKDF KFYTNEFGTY LVTIGSDGKI VVWDMSTKEQ VAVYDCGERL 401 NCLTLCDESI EKYNTMKKRD AETADIGDQS EVESDTEELK KIMFGEKKKL 451 NKKKRKQLKK SKVSVELE*

Amino Acid Sequence (or in FASTA format)

       1  MLLNTTYTVF IFFLLRIIKF KIKAENFLEH EKLKTHGTSS RKDPKGQVKN
      51  SCRKMSAIGD KNQFRIIVGS YEHNILCLSL DIPNQKENDA AKTPHFMPIF
     101  HFQAHSLSIK CLAVSRRYLV SGSNDEHIRI YDLQKRKELG TLLSHQGSIT
     151  ALQFSHPASS SEDAAVSKGS KNSKWLLSAS EDHKIMVWRV KDWETVGTLK
     201  GHTARVNDVD IHPTNRIAIS VSDDHSIRLW NLMTLRNAAV LKLRKYNTNG
     251  TCVRWLGAKG DYFAVGLRDR VLIYETGSAK VFKEIVFQRK TLMHIETHIL
     301  PFDNKEYLSV GISDGNVHFY PCEELFEKVE ENEKQEDDDD KEDISPAFSL
     351  LGHTNRIKDF KFYTNEFGTY LVTIGSDGKI VVWDMSTKEQ VAVYDCGERL
     401  NCLTLCDESI EKYNTMKKRD AETADIGDQS EVESDTEELK KIMFGEKKKL
     451  NKKKRKQLKK SKVSVELE*

external links for Mak11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mak11p

1)	Icho T and Wickner RB (1988) The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. J Biol Chem 263(3):1467-75
2)	Saveanu C, et al. (2007) The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Mol Cell Biol 27(8):2897-909
3)	Wickner RB (1974) Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae. Genetics 76(3):423-32
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41