CCE1/YKL011C Protein Information

Standard Name	Cce1p
Systematic Name	Ykl011cp
Alias	Mgt1p
ORF Classification	Verified
Description	Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Cruciform Cutting Endonuclease 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	353
Molecular Weight (Da)	41,000
Isoelectric Point (pI)	10

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cce1p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001272A7 \| Q03702 MIPS: YKL011C NCBI: 1680475 \| 171175 \| 416770 \| 485995 \| 6322841 \| NP_012914.1 GenBank/EMBL/DDBJ: DAA09145.1 \| M65275 \| S53418 \| Z28011
External Classifications	EC: 3.1.-.- [Hydrolases acting on ester bonds ]

Amino Acid Sequence (or in FASTA format)
1 MSTAQKAKIL QLIDSCCQNA KSTQLKSLSF VIGAVNGTTK EAKRTYIQEQ 51 CEFLEKLRQQ KIREGRINIL SMDAGVSNFA FSKMQLLNND PLPKVLDWQK 101 INLEEKFFQN LKKLSLNPAE TSELVFNLTE YLFESMPIPD MFTIERQRTR 151 TMSSRHILDP ILKVNILEQI LFSNLENKMK YTNKIPNTSK LRYMVCSSDP 201 HRMTSYWCIP REETPTSSKK LKSNKHSKDS RIKLVKKILS TSILEGNSTS 251 STKLVEFIGV WNNRIRNALT KKKSFKLCDI LEIQDNSGVR KDDDLADSFL 301 HCLSWMEWLK NYESITELLN SKTLVKTQFG QVFEFCENKV QKLKFLQNTY 351 NND*

Amino Acid Sequence (or in FASTA format)

       1  MSTAQKAKIL QLIDSCCQNA KSTQLKSLSF VIGAVNGTTK EAKRTYIQEQ
      51  CEFLEKLRQQ KIREGRINIL SMDAGVSNFA FSKMQLLNND PLPKVLDWQK
     101  INLEEKFFQN LKKLSLNPAE TSELVFNLTE YLFESMPIPD MFTIERQRTR
     151  TMSSRHILDP ILKVNILEQI LFSNLENKMK YTNKIPNTSK LRYMVCSSDP
     201  HRMTSYWCIP REETPTSSKK LKSNKHSKDS RIKLVKKILS TSILEGNSTS
     251  STKLVEFIGV WNNRIRNALT KKKSFKLCDI LEIQDNSGVR KDDDLADSFL
     301  HCLSWMEWLK NYESITELLN SKTLVKTQFG QVFEFCENKV QKLKFLQNTY
     351  NND*

external links for Cce1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cce1p

1)	Ezekiel UR and Zassenhaus HP (1993) Localization of a cruciform cutting endonuclease to yeast mitochondria. Mol Gen Genet 240(3):414-8
2)	White MF and Lilley DM (1997) The resolving enzyme CCE1 of yeast opens the structure of the four-way DNA junction. J Mol Biol 266(1):122-34
3)	Kleff S, et al. (1992) Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease. EMBO J 11(2):699-704
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61