GTT1/YIR038C Protein Information

Standard Name	Gtt1p 1
Systematic Name	Yir038cp
ORF Classification	Verified
Description	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p (1, 2)
Name Description	GlutaThione Transferase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	234
Molecular Weight (Da)	26,795
Isoelectric Point (pI)	6.65

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gtt1p (InterPro)
Physical Interactions	There are 69 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012BCC4 \| P40582 MIPS: YIR038C NCBI: 557844 \| 6322229 \| 731924 \| NP_012304.1 GenBank/EMBL/DDBJ: DAA08585.1 \| Z38061
External Classifications	EC: 2.5.1.18 [Glutathione transferase]

Amino Acid Sequence (or in FASTA format)
1 MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI 51 HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA 101 DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA 151 YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA 201 PEDYPAISKW LKTITSEESY AASKEKARAL GSNF*

Amino Acid Sequence (or in FASTA format)

       1  MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI
      51  HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA
     101  DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA
     151  YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA
     201  PEDYPAISKW LKTITSEESY AASKEKARAL GSNF*

external links for Gtt1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gtt1p

1)	Choi JH, et al. (1998) A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. J Biol Chem 273(45):29915-22
2)	Collinson EJ and Grant CM (2003) Role of yeast glutaredoxins as glutathione S-transferases. J Biol Chem 278(25):22492-7