HYR1/YIR037W Protein Information Help

Standard Name Hyr1p 1
Systematic Name Yir037wp
Alias Gpx3p 2 , Orp1p
ORF Classification Verified
Description Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; HYR1 has a paralog, GPX1, that arose from the whole genome duplication (3, 4)
Name Description HYdroperoxide Resistance
Experimental Data
Molecules/cell 8120 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 163
Molecular Weight (Da) 18,641
Isoelectric Point (pI) 8.33

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hyr1p (InterPro)
Physical Interactions There are 41 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F92C | P40581
MIPS: YIR037W
NCBI: 203282397 | 557843 | 6322228 | 727367 | 729640 | NP_012303.1
GenBank/EMBL/DDBJ: DAA08584.1 | U22446 | Z38061
External Classifications EC: 1.11.1.15 [Peroxiredoxin]
Amino Acid Sequence (or in FASTA format)
 
       1  MSEFYKLAPV DKKGQPFPFD QLKGKVVLIV NVASKCGFTP QYKELEALYK
      51  RYKDEGFTII GFPCNQFGHQ EPGSDEEIAQ FCQLNYGVTF PIMKKIDVNG
     101  GNEDPVYKFL KSQKSGMLGL RGIKWNFEKF LVDKKGKVYE RYSSLTKPSS
     151  LSETIEELLK EVE*

external links for Hyr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hyr1p
1) Budde, E. and Stahl, U.  (1995) Cloning and phenotypic characterization of a glutathione-peroxidase like gene involved in the oxidative stress response of Saccharomyces cerevisiae. Unpublished
2) Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9
3) Delaunay A, et al.  (2002) A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell 111(4):471-81
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41