IRC24/YIR036C Protein Information

Standard Name	Irc24p 1
Systematic Name	Yir036cp
ORF Classification	Uncharacterized
Description	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci (1, 2, 3, 4, 5, 6)
Name Description	Increased Recombination Centers 1

Experimental Data
Molecules/cell	1620 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	263
Molecular Weight (Da)	28,804
Isoelectric Point (pI)	6.3

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Irc24p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000000109A \| P40580 MIPS: YIR036C NCBI: 19386576 \| 398364743 \| 45270370 \| 557842 \| 731923 \| NP_012302.3 GenBank/EMBL/DDBJ: DAA08583.1 \| AB052924 \| AY558240 \| Z38061
External Classifications	EC: 1.-.-.- [Oxidoreductases] EC: 1.1.1.320 [Benzil reductase ((S)-benzoin forming)]

Amino Acid Sequence (or in FASTA format)
1 MGKVILITGA SRGIGLQLVK TVIEEDDECI VYGVARTEAG LQSLQREYGA 51 DKFVYRVLDI TDRSRMEALV EEIRQKHGKL DGIVANAGML EPVKSISQSN 101 SEHDIKQWER LFDVNFFSIV SLVALCLPLL KSSPFVGNIV FVSSGASVKP 151 YNGWSAYGCS KAALNHFAMD IASEEPSDKV RAVCIAPGVV DTQMQKDIRE 201 TLGPQGMTPK ALERFTQLYK TSSLLDPKVP AAVLAQLVLK GIPDSLNGQY 251 LRYNDERLGP VQG*

Amino Acid Sequence (or in FASTA format)

       1  MGKVILITGA SRGIGLQLVK TVIEEDDECI VYGVARTEAG LQSLQREYGA
      51  DKFVYRVLDI TDRSRMEALV EEIRQKHGKL DGIVANAGML EPVKSISQSN
     101  SEHDIKQWER LFDVNFFSIV SLVALCLPLL KSSPFVGNIV FVSSGASVKP
     151  YNGWSAYGCS KAALNHFAMD IASEEPSDKV RAVCIAPGVV DTQMQKDIRE
     201  TLGPQGMTPK ALERFTQLYK TSSLLDPKVP AAVLAQLVLK GIPDSLNGQY
     251  LRYNDERLGP VQG*

external links for Irc24p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Irc24p

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	Athenstaedt K and Daum G (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40
3)	Beaudoin F, et al. (2002) A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. J Biol Chem 277(13):11481-8
4)	Han G, et al. (2002) The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. J Biol Chem 277(38):35440-9
5)	Maruyama R, et al. (2002) The enzymes with benzil reductase activity conserved from bacteria to mammals. J Biotechnol 94(2):157-69
6)	Lee MW, et al. (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41