MND2/YIR025W Protein Information

Standard Name	Mnd2p 1
Systematic Name	Yir025wp
ORF Classification	Verified
Description	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase (1, 2, 3)
Name Description	Meiotic Nuclear Divisions 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	368
Molecular Weight (Da)	42,825
Isoelectric Point (pI)	4.47

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mnd2p (InterPro)
Physical Interactions	There are 64 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B484 \| P40577 MIPS: YIR025W NCBI: 557831 \| 6322216 \| 731920 \| NP_012291.1 GenBank/EMBL/DDBJ: DAA08572.1 \| Z38061

Amino Acid Sequence (or in FASTA format)
1 MARALRDISL FNDIRKDQNS AGAKHERYNM RDLRSKKNQH VNGIDDYEDD 51 SLDRFIRRKK SRVVKYIPSL SAYNVFNEFP YYPTSASQLL DGKLDEFLML 101 SEQYKSRLPK IRKLGWNRFK PIGINKTMYE LEMLRSRARA QNAEGNNEED 151 FRQHDSREED PRNNGSIGRV ILPHILQENE EYDTGEGVTG LHSMPNDSMA 201 ILANNSANNS QNEEVSEEDE ISYDYDAEFD HVVDEDDNEE GEVPGEGVEG 251 IEVQRERIVP DDLLMRPTSL SRSLQQFVEE AHHLDRNPYD IDSDNDGEDS 301 KVELDMNPDF EDDVGREHDY NSEYSQEPTS YGGITPDLAS NWRNWTRERI 351 TSLDELMERR ARQQRGQD*

Amino Acid Sequence (or in FASTA format)

       1  MARALRDISL FNDIRKDQNS AGAKHERYNM RDLRSKKNQH VNGIDDYEDD
      51  SLDRFIRRKK SRVVKYIPSL SAYNVFNEFP YYPTSASQLL DGKLDEFLML
     101  SEQYKSRLPK IRKLGWNRFK PIGINKTMYE LEMLRSRARA QNAEGNNEED
     151  FRQHDSREED PRNNGSIGRV ILPHILQENE EYDTGEGVTG LHSMPNDSMA
     201  ILANNSANNS QNEEVSEEDE ISYDYDAEFD HVVDEDDNEE GEVPGEGVEG
     251  IEVQRERIVP DDLLMRPTSL SRSLQQFVEE AHHLDRNPYD IDSDNDGEDS
     301  KVELDMNPDF EDDVGREHDY NSEYSQEPTS YGGITPDLAS NWRNWTRERI
     351  TSLDELMERR ARQQRGQD*

external links for Mnd2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mnd2p

1)	Rabitsch KP, et al. (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2)	Hall MC, et al. (2003) Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem 278(19):16698-705
3)	Torres MP and Borchers CH (2007) Mitotic Phosphorylation of the Anaphase-promoting Complex Inhibitory Subunit Mnd2 Is Necessary for Efficient Progression through Meiosis I. J Biol Chem 282(24):17351-62