YAP5/YIR018W Protein Information

Standard Name	Yap5p 1
Systematic Name	Yir018wp
ORF Classification	Verified
Description	Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication (1, 2, 3)
Name Description	Yeast AP-1 1

Experimental Data
Molecules/cell	238 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	245
Molecular Weight (Da)	28,386
Isoelectric Point (pI)	8.81

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yap5p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B480 \| P40574 MIPS: YIR018W NCBI: 45270366 \| 556865 \| 575462 \| 6322208 \| 731917 \| NP_012283.1 GenBank/EMBL/DDBJ: DAA08564.1 \| AY558238 \| U17015 \| Z37996

Amino Acid Sequence (or in FASTA format)
1 MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE 51 DYETEENDEE LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY 101 ETKLNRLQNE LQAKESENHA LKQKLETLTL KQASVPAQDP ILQNLIENFK 151 PMKAIPIKYN TAIKRHQHST ELPSSVKCGF CNDNTTCVCK ELETDHRKSD 201 DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI RSIIH*

Amino Acid Sequence (or in FASTA format)

       1  MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE
      51  DYETEENDEE LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY
     101  ETKLNRLQNE LQAKESENHA LKQKLETLTL KQASVPAQDP ILQNLIENFK
     151  PMKAIPIKYN TAIKRHQHST ELPSSVKCGF CNDNTTCVCK ELETDHRKSD
     201  DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI RSIIH*

external links for Yap5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Yap5p

1)	Fernandes L, et al. (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Li L, et al. (2008) Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast. Mol Cell Biol 28(4):1326-37
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41