RPL40A/YIL148W Protein Information Help

Standard Name Rpl40ap
Systematic Name Yil148wp
Alias Cep52ap , Ubi1p 1 , Ub11p
ORF Classification Verified
Description Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress (2, 3, 4, 5, 6, 7)
Name Description Ribosomal Protein of the Large subunit
Gene Product L40A 2 , L40e 7
Experimental Data
Molecules/cell 11800 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 128
Molecular Weight (Da) 14,554
Isoelectric Point (pI) 10.63

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rpl40ap (InterPro)
Physical Interactions There are 58 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000036C5E | P0CH08
MIPS: YIL148W
NCBI: 302595806 | 398365469 | 4728 | 4730 | 559522 | 6322043 | NP_012118.1 | NP_013020.3 | NP_878113.4
GenBank/EMBL/DDBJ: DAA08405.1 | X05728 | X05729 | Z38059
Amino Acid Sequence (or in FASTA format)
 
       1  MQIFVKTLTG KTITLEVESS DTIDNVKSKI QDKEGIPPDQ QRLIFAGKQL
      51  EDGRTLSDYN IQKESTLHLV LRLRGGIIEP SLKALASKYN CDKSVCRKCY
     101  ARLPPRATNC RKRKCGHTNQ LRPKKKLK*

external links for Rpl40ap
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Rpl40ap
1) Ozkaynak E, et al.  (1987) The yeast ubiquitin genes: a family of natural gene fusions. EMBO J 6(5):1429-39
2) Planta RJ and Mager WH  (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
3) Finley D, et al.  (1989) The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature 338(6214):394-401
4) Lecompte O, et al.  (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Jenner L, et al.  (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41