PAN6/YIL145C Protein Information

Standard Name	Pan6p
Systematic Name	Yil145cp
ORF Classification	Verified
Description	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC (1)
Name Description	PANtothenate biosynthesis 1

Experimental Data
Molecules/cell	2400 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	309
Molecular Weight (Da)	35,032
Isoelectric Point (pI)	5.18

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pan6p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D478A \| P40459 MIPS: YIL145C NCBI: 37362661 \| 557778 \| 84028236 \| NP_012121.2 GenBank/EMBL/DDBJ: DAA08408.1 \| Z38059
External Classifications	EC: 6.3.2.1 [Pantoate--beta-alanine ligase]

Amino Acid Sequence (or in FASTA format)
1 MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE 51 NTYTVVSIFV NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV 101 MYPQGIPLDI EEQKGPFVSV LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV 151 MADVAYFGQK DIQQFIVLQC MVDELFVNTR LQMMPIVRNN NGLALSSRNK 201 YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID TVTQIWAPYV 251 DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 301 VRLIDNIVI*

Amino Acid Sequence (or in FASTA format)

       1  MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE
      51  NTYTVVSIFV NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV
     101  MYPQGIPLDI EEQKGPFVSV LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV
     151  MADVAYFGQK DIQQFIVLQC MVDELFVNTR LQMMPIVRNN NGLALSSRNK
     201  YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID TVTQIWAPYV
     251  DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV
     301  VRLIDNIVI*

external links for Pan6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Pan6p

1)	White WH, et al. (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41