TAO3/YIL129C Protein Information

Standard Name	Tao3p 1
Systematic Name	Yil129cp
Alias	Pag1p 2
ORF Classification	Verified
Description	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p (1, 2)
Name Description	Transcriptional Activator of OCH1 3

Experimental Data
Molecules/cell	206 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	2,376
Molecular Weight (Da)	269,855
Isoelectric Point (pI)	6.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tao3p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001368D4 \| P40468 MIPS: YIL129C NCBI: 398364249 \| 557794 \| 71081913 \| 71081917 \| 71081923 \| 71081937 \| 731871 \| NP_012137.3 GenBank/EMBL/DDBJ: DAA08424.1 \| DQ116812 \| DQ116814 \| DQ116817 \| DQ116824 \| Z38059

Amino Acid Sequence (or in FASTA format)
1 MASRFTFPPQ RDQGIGFTFP PTNKAEGSSN NNQISIDIDP SGQDVLEEIN 51 EAPLNTFPLH QSVTDAPIID IPSPTDMSEG TSLNNQLLLR QQQQQGTGEG 101 QALPPTFVEE QSDQNKISML LPEQKQQRMQ ESAPPDITAK SVAEDYVTTL 151 RQQMATDWKS PSEYALHILF TKFIRYAENK LNMCLQQLDM AEPPIVEILG 201 EGVDPSFDEI IKSLGHIAKK KPKPVIDAMM FWRKTKSEAA NSASEEMEKL 251 LKEYEFEKAH PSQAHFLMNR RLSRSSSNTT SKYKHNNNTN NLPGMKRHVS 301 SSFNNKVPLI KASSSNNSAT SSPSIANSQL KSLENTIEVA KEEAFLADRK 351 SLISIYILCR VLNEIVKQAS SNEEEDLSDK LEEIVFTQLK TTDPLSISTS 401 LIKSSNWNSF AELLGSMSEK KFLSVSDRFI ADLEKIPAYI PPELEPSTHL 451 LILGMRYLKL RNYPLEKFEE SADFMKSLSK FFAKTENFPV CLAYAEVTNQ 501 LLLPLAGSLT AEVNHPTWVE AMSTLLNTAK RLQADSKYWV SGFKLTVSIL 551 CASPPDLFSK QWLSLLEANA SKVKSKSLNE RIIFAVGLSR LVWVYLYRCP 601 ETLNNTTRTL TKLLQLYLNT RKKENWITGD FGLLNPLTDA LISIGFLHPN 651 FLMEQALIPL IRQSFNGSNL ENINYEKLIL TINTYKGLLV TKERPRFPED 701 DNRLYELNLN NITVNQVQEA SSINHTEISD YFYKLFLLLD SSIGSEVWSP 751 ENQHQKQSSN AFSPFGFSFS NDNDSSKNKS LYVILFGTII EAIPCCLSIS 801 RTIPYKSTIE ILSRNAVHSE VIISSSSQNA LRALASKKNP YTLITWFAKY 851 SFDFDEKTQS SYNMSYLSSK EYNRLLILYV ELLECWLEEF QSSNKEENKK 901 ETGLDGIRLL PIDAEQEESN ETEKLEWKNT VTVIEEVEGN GLFFLCSHDA 951 KIRRLGIQIL RIIFKFDEAM MEKTEKLSNG HSRSSSHFAA DRGTRLIDLL 1001 NECNTTTLIN PHKATLSAVE KTRFSRLNSK YKRGLLIKLA ESEYGVDAAL 1051 WQRAFPKLLA LVFKTCPMAM ALCRSIVCIR LVQVHEIILR VANDVDFKLK 1101 NVLPETIVNQ WKLYLIAACT SLTSTFDQKL HIPSNIPQHG RKKSQQIFTV 1151 QHQKIKSAKS IFKMVLPLLN AKYIMIRDAI ITGLSSMNIN IFKAYVEAID 1201 VFLVAWKEGS SNNQIRVEMF HILTILSPYL KSDMIFNDEW ILRKLSEFLQ 1251 KTKQFLEKDS VQISYEYQSL RSYFAGLILS YYMAVREHPL IDELFPFQAR 1301 ASCFNFLKEW CGYGEYEPIS EERYAIMIKN TESGRDRTAI TTGIEFQKNR 1351 LQMIVLETMV VLCSDPITQT LDDDLELPIV ISFDTEDLLA WIEALFDSDN 1401 TTVKNLGVRA LENLLDKNRE NFKLFRDVAF QCVSHHSHPS VAVLYYTTLC 1451 KSVLKLDNLV LDEDELVSLG LYGLVADKED TRTFAVDLLS AVETKLHNSS 1501 YTKVFKERLA NSSKTVYKST AKEISSIFAE LLSQDLCLRI FSSLVRILDL 1551 FPFEIKRDLL VLMVPWVNKF TLKSLEELDT FMVLNNLFYI TIDLNDSLPN 1601 EVEQLWISLG KGNSFQNIHV SLEYIINSSM NHCNPLFVQY ARDIVLYLAN 1651 IPGGIGLLDT LLNNLEPKYM VPLAKHTFNE PMNNNKYSFL GNIWERLNYN 1701 GKRIIFSKAQ LSIIFLVNLL TNLSESVKAK IPLLLHMSIC LLDHYVPLIH 1751 ESACKIASTL IFGLAPSHEK SEETVKLLRN KHALWSYDNL MKKGARSPKT 1801 MDLLIRNIIS IFSDLDEFQV TWQRIALKWA TTCSVRHIAC RSFQIFRSLL 1851 TFLDQEMLRD MLHRLSNTIS DGNVDIQGFA MQILMTLNAI MAELDPTNLI 1901 SFPQLFWSIT ACLSSIHEQE FIEVLSCLSK FISKIDLDSP DTVQCLVAIF 1951 PSNWEGRFDG LQQIVMTGLR SANSLEITWK FLDKLNLLKD SRIIANTESR 2001 LLFALIANLP RFLNAMDRKD FTGIQVAADS LIELANAYKQ PSLSRLIDSL 2051 AKNKFRSKKD FMSQVVSFIS RNYFPSYSAQ TLVFLLGLLF NKIGWIRVQT 2101 LEILKYVFPL IDLRRPEFIG VGADLISPLL RLLFTEYEAK ALEVLDCVPN 2151 VSGSKMDKDV LRITMGNKDV KDGDNATTTL FGLPEDSGWS VPMPTMTAAT 2201 TRHNVHAVFM TCGTGKSDEV SAHGSDDMDA VIEFHADGDY ELGRMDTIVE 2251 FHADGDYDLG RMDTNDSISV AEEKDASLSH MWAELDNLDS FFTKDTNVPN 2301 ISSKMGMGIP HGRSDSIETT RTDQTFSFES APQLYDKKVS VILNRSLSRT 2351 PSNVSFKTHL ADSFAVKINR NGKPRI*

Amino Acid Sequence (or in FASTA format)

       1  MASRFTFPPQ RDQGIGFTFP PTNKAEGSSN NNQISIDIDP SGQDVLEEIN
      51  EAPLNTFPLH QSVTDAPIID IPSPTDMSEG TSLNNQLLLR QQQQQGTGEG
     101  QALPPTFVEE QSDQNKISML LPEQKQQRMQ ESAPPDITAK SVAEDYVTTL
     151  RQQMATDWKS PSEYALHILF TKFIRYAENK LNMCLQQLDM AEPPIVEILG
     201  EGVDPSFDEI IKSLGHIAKK KPKPVIDAMM FWRKTKSEAA NSASEEMEKL
     251  LKEYEFEKAH PSQAHFLMNR RLSRSSSNTT SKYKHNNNTN NLPGMKRHVS
     301  SSFNNKVPLI KASSSNNSAT SSPSIANSQL KSLENTIEVA KEEAFLADRK
     351  SLISIYILCR VLNEIVKQAS SNEEEDLSDK LEEIVFTQLK TTDPLSISTS
     401  LIKSSNWNSF AELLGSMSEK KFLSVSDRFI ADLEKIPAYI PPELEPSTHL
     451  LILGMRYLKL RNYPLEKFEE SADFMKSLSK FFAKTENFPV CLAYAEVTNQ
     501  LLLPLAGSLT AEVNHPTWVE AMSTLLNTAK RLQADSKYWV SGFKLTVSIL
     551  CASPPDLFSK QWLSLLEANA SKVKSKSLNE RIIFAVGLSR LVWVYLYRCP
     601  ETLNNTTRTL TKLLQLYLNT RKKENWITGD FGLLNPLTDA LISIGFLHPN
     651  FLMEQALIPL IRQSFNGSNL ENINYEKLIL TINTYKGLLV TKERPRFPED
     701  DNRLYELNLN NITVNQVQEA SSINHTEISD YFYKLFLLLD SSIGSEVWSP
     751  ENQHQKQSSN AFSPFGFSFS NDNDSSKNKS LYVILFGTII EAIPCCLSIS
     801  RTIPYKSTIE ILSRNAVHSE VIISSSSQNA LRALASKKNP YTLITWFAKY
     851  SFDFDEKTQS SYNMSYLSSK EYNRLLILYV ELLECWLEEF QSSNKEENKK
     901  ETGLDGIRLL PIDAEQEESN ETEKLEWKNT VTVIEEVEGN GLFFLCSHDA
     951  KIRRLGIQIL RIIFKFDEAM MEKTEKLSNG HSRSSSHFAA DRGTRLIDLL
    1001  NECNTTTLIN PHKATLSAVE KTRFSRLNSK YKRGLLIKLA ESEYGVDAAL
    1051  WQRAFPKLLA LVFKTCPMAM ALCRSIVCIR LVQVHEIILR VANDVDFKLK
    1101  NVLPETIVNQ WKLYLIAACT SLTSTFDQKL HIPSNIPQHG RKKSQQIFTV
    1151  QHQKIKSAKS IFKMVLPLLN AKYIMIRDAI ITGLSSMNIN IFKAYVEAID
    1201  VFLVAWKEGS SNNQIRVEMF HILTILSPYL KSDMIFNDEW ILRKLSEFLQ
    1251  KTKQFLEKDS VQISYEYQSL RSYFAGLILS YYMAVREHPL IDELFPFQAR
    1301  ASCFNFLKEW CGYGEYEPIS EERYAIMIKN TESGRDRTAI TTGIEFQKNR
    1351  LQMIVLETMV VLCSDPITQT LDDDLELPIV ISFDTEDLLA WIEALFDSDN
    1401  TTVKNLGVRA LENLLDKNRE NFKLFRDVAF QCVSHHSHPS VAVLYYTTLC
    1451  KSVLKLDNLV LDEDELVSLG LYGLVADKED TRTFAVDLLS AVETKLHNSS
    1501  YTKVFKERLA NSSKTVYKST AKEISSIFAE LLSQDLCLRI FSSLVRILDL
    1551  FPFEIKRDLL VLMVPWVNKF TLKSLEELDT FMVLNNLFYI TIDLNDSLPN
    1601  EVEQLWISLG KGNSFQNIHV SLEYIINSSM NHCNPLFVQY ARDIVLYLAN
    1651  IPGGIGLLDT LLNNLEPKYM VPLAKHTFNE PMNNNKYSFL GNIWERLNYN
    1701  GKRIIFSKAQ LSIIFLVNLL TNLSESVKAK IPLLLHMSIC LLDHYVPLIH
    1751  ESACKIASTL IFGLAPSHEK SEETVKLLRN KHALWSYDNL MKKGARSPKT
    1801  MDLLIRNIIS IFSDLDEFQV TWQRIALKWA TTCSVRHIAC RSFQIFRSLL
    1851  TFLDQEMLRD MLHRLSNTIS DGNVDIQGFA MQILMTLNAI MAELDPTNLI
    1901  SFPQLFWSIT ACLSSIHEQE FIEVLSCLSK FISKIDLDSP DTVQCLVAIF
    1951  PSNWEGRFDG LQQIVMTGLR SANSLEITWK FLDKLNLLKD SRIIANTESR
    2001  LLFALIANLP RFLNAMDRKD FTGIQVAADS LIELANAYKQ PSLSRLIDSL
    2051  AKNKFRSKKD FMSQVVSFIS RNYFPSYSAQ TLVFLLGLLF NKIGWIRVQT
    2101  LEILKYVFPL IDLRRPEFIG VGADLISPLL RLLFTEYEAK ALEVLDCVPN
    2151  VSGSKMDKDV LRITMGNKDV KDGDNATTTL FGLPEDSGWS VPMPTMTAAT
    2201  TRHNVHAVFM TCGTGKSDEV SAHGSDDMDA VIEFHADGDY ELGRMDTIVE
    2251  FHADGDYDLG RMDTNDSISV AEEKDASLSH MWAELDNLDS FFTKDTNVPN
    2301  ISSKMGMGIP HGRSDSIETT RTDQTFSFES APQLYDKKVS VILNRSLSRT
    2351  PSNVSFKTHL ADSFAVKINR NGKPRI*

external links for Tao3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tao3p

1)	Nelson B, et al. (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803
2)	Du LL and Novick P (2002) Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Mol Biol Cell 13(2):503-14
3)	Horecka, J. and Jigami, Y. (1999) personal communication
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41