KGD1/YIL125W Protein Information Help

Standard Name Kgd1p 1
Systematic Name Yil125wp
Alias Ogd1p
ORF Classification Verified
Description Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA (2)
Name Description alpha-KetoGlutarate Dehydrogenase
Experimental Data
Molecules/cell 14300 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,014
Molecular Weight (Da) 114,415
Isoelectric Point (pI) 7.21

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kgd1p (InterPro)
Physical Interactions There are 46 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052EF1 | P20967
MIPS: YIL125W
NCBI: 171785 | 599992 | 6322066 | 730221 | NP_012141.1
GenBank/EMBL/DDBJ: DAA08428.1 | M26390 | Z46833
External Classifications EC: 1.2.4.2 [Oxoglutarate dehydrogenase (succinyl-transferring)]
Amino Acid Sequence (or in FASTA format)
 
       1  MLRFVSSQTC RYSSRGLLKT SLLKNASTVK IVGRGLATTG TDNFLSTSNA
      51  TYIDEMYQAW QKDPSSVHVS WDAYFKNMSN PKIPATKAFQ APPSISNFPQ
     101  GTEAAPLGTA MTGSVDENVS IHLKVQLLCR AYQVRGHLKA HIDPLGISFG
     151  SNKNNPVPPE LTLDYYGFSK HDLDKEINLG PGILPRFARD GKSKMSLKEI
     201  VDHLEKLYCS SYGVQYTHIP SKQKCDWLRE RIEIPEPYQY TVDQKRQILD
     251  RLTWATSFES FLSTKFPNDK RFGLEGLESV VPGIKTLVDR SVELGVEDIV
     301  LGMAHRGRLN VLSNVVRKPN ESIFSEFKGS SARDDIEGSG DVKYHLGMNY
     351  QRPTTSGKYV NLSLVANPSH LESQDPVVLG RTRALLHAKN DLKEKTKALG
     401  VLLHGDAAFA GQGVVYETMG FLTLPEYSTG GTIHVITNNQ IGFTTDPRFA
     451  RSTPYPSDLA KAIDAPIFHV NANDVEAVTF IFNLAAEWRH KFHTDAIIDV
     501  VGWRKHGHNE TDQPSFTQPL MYKKIAKQKS VIDVYTEKLI SEGTFSKKDI
     551  DEHKKWVWNL FEDAFEKAKD YVPSQREWLT AAWEGFKSPK ELATEILPHE
     601  PTNVPESTLK ELGKVLSSWP EGFEVHKNLK RILKNRGKSI ETGEGIDWAT
     651  GEALAFGTLV LDGQNVRVSG EDVERGTFSQ RHAVLHDQQS EAIYTPLSTL
     701  NNEKADFTIA NSSLSEYGVM GFEYGYSLTS PDYLVMWEAQ FGDFANTAQV
     751  IIDQFIAGGE QKWKQRSGLV LSLPHGYDGQ GPEHSSGRLE RFLQLANEDP
     801  RYFPSEEKLQ RQHQDCNFQV VYPTTPANLF HILRRQQHRQ FRKPLALFFS
     851  KQLLRHPLAR SSLSEFTEGG FQWIIEDIEH GKSIGTKEET KRLVLLSGQV
     901  YTALHKRRES LGDKTTAFLK IEQLHPFPFA QLRDSLNSYP NLEEIVWCQE
     951  EPLNMGSWAY TEPRLHTTLK ETDKYKDFKV RYCGRNPSGA VAAGSKSLHL
    1001  AEEDAFLKDV FQQS*

external links for Kgd1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Kgd1p
1) Subik, J.  (1992) Personal Communication, Mortimer Map Edition 11
2) Repetto B and Tzagoloff A  (1989) Structure and regulation of KGD1, the structural gene for yeast alpha-ketoglutarate dehydrogenase. Mol Cell Biol 9(6):2695-705
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41