AYR1/YIL124W Protein Information

Standard Name	Ayr1p
Systematic Name	Yil124wp
ORF Classification	Verified
Description	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones (1, 2, 3)
Name Description	1-AcyldihYdroxyacetone-phosphate Reductase 1
Gene Product	1-acyl dihydroxyacetone phosphate reductase 1

Experimental Data
Molecules/cell	3670 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	297
Molecular Weight (Da)	32,814
Isoelectric Point (pI)	9.92

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ayr1p (InterPro)
Physical Interactions	There are 26 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B43E \| P40471 MIPS: YIL124W NCBI: 398364253 \| 599993 \| 731868 \| NP_012142.3 GenBank/EMBL/DDBJ: DAA08429.1 \| Z46833
External Classifications	EC: 1.1.1.101 [Acylglycerone-phosphate reductase]

Amino Acid Sequence (or in FASTA format)
1 MSELQSQPKK IAVVTGASGG IGYEVTKELA RNGYLVYACA RRLEPMAQLA 51 IQFGNDSIKP YKLDISKPEE IVTFSGFLRA NLPDGKLDLL YNNAGQSCTF 101 PALDATDAAV EQCFKVNVFG HINMCRELSE FLIKAKGTIV FTGSLAGVVS 151 FPFGSIYSAS KAAIHQYARG LHLEMKPFNV RVINAITGGV ATDIADKRPL 201 PETSIYNFPE GREAFNSRKT MAKDNKPMPA DAYAKQLVKD ILSTSDPVDV 251 YRGTFANIMR FVMIFVPYWL LEKGLSKKFK LDKVNNALKS KQKNKDD*

Amino Acid Sequence (or in FASTA format)

       1  MSELQSQPKK IAVVTGASGG IGYEVTKELA RNGYLVYACA RRLEPMAQLA
      51  IQFGNDSIKP YKLDISKPEE IVTFSGFLRA NLPDGKLDLL YNNAGQSCTF
     101  PALDATDAAV EQCFKVNVFG HINMCRELSE FLIKAKGTIV FTGSLAGVVS
     151  FPFGSIYSAS KAAIHQYARG LHLEMKPFNV RVINAITGGV ATDIADKRPL
     201  PETSIYNFPE GREAFNSRKT MAKDNKPMPA DAYAKQLVKD ILSTSDPVDV
     251  YRGTFANIMR FVMIFVPYWL LEKGLSKKFK LDKVNNALKS KQKNKDD*

external links for Ayr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ayr1p

1)	Athenstaedt K and Daum G (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40
2)	Vico P, et al. (2002) Dehydroepiandrosterone (DHEA) metabolism in Saccharomyces cerevisiae expressing mammalian steroid hydroxylase CYP7B: Ayr1p and Fox2p display 17beta-hydroxysteroid dehydrogenase activity. Yeast 19(10):873-86
3)	Zahedi RP, et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17(3):1436-50
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41