QDR2/YIL121W Protein Information Help

Standard Name Qdr2p 1
Systematic Name Yil121wp
ORF Classification Verified
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper (1, 2, 3, 4, 5)
Name Description QuiniDine Resistance 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 542
Molecular Weight (Da) 59,617
Isoelectric Point (pI) 9.64

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Qdr2p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B43A | P40474
MIPS: YIL121W
NCBI: 51012921 | 599996 | 6322070 | 731865 | NP_012145.1
GenBank/EMBL/DDBJ: DAA08432.1 | AY692735 | Z46833
External Classifications TC: 2.A.1.2 [The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP
      51  PHSRFSRSFK TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN
     101  VTVVVYFVFQ GLAPTFMGGF ADSLGRRPVV LVAIVIYFGA CIGLACAQTY
     151  AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT RAERGGYVGY VAGFQVLGSA
     201  FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET KRNISGNGSV
     251  TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE
     301  ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC
     351  SIVIAGRYLN WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP
     401  KYTFNIFKAR LQPAFVTLLL SSSGFCAYGW CITVKAPLAA VLCMSGFASL
     451  FSNCILTFST TLIVDLFPTK TSTATGCLNL FRCILSAVFI AALSKMVEKM
     501  KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG VN*

external links for Qdr2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Qdr2p
1) Vargas RC, et al.  (2004) Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant. Antimicrob Agents Chemother 48(7):2531-7
2) Tenreiro S, et al.  (2005) The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Biochem Biophys Res Commun 327(3):952-9
3) Vargas RC, et al.  (2007) Saccharomyces cerevisiae Multidrug Resistance Transporter Qdr2 Is Implicated in Potassium Uptake, Providing a Physiological Advantage to Quinidine-Stressed Cells. Eukaryot Cell 6(2):134-42
4) Dias PJ, et al.  (2010) Evolution of the 12-Spanner Drug:H+ Antiporter DHA1 Family in Hemiascomycetous Yeasts. OMICS 14(6):701-10
5) Rios G, et al.  (2013) Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response. FEMS Yeast Res 13(1):97-106