QDR1/YIL120W Protein Information Help

Standard Name Qdr1p 1
Systematic Name Yil120wp
ORF Classification Verified
Description Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description QuiniDine Resistance 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 563
Molecular Weight (Da) 61,758
Isoelectric Point (pI) 9.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Qdr1p (InterPro)
Transmembrane Domains There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B439 | P40475
MIPS: YIL120W
NCBI: 599997 | 6322071 | 731864 | NP_012146.1
GenBank/EMBL/DDBJ: DAA08433.1 | Z46833
External Classifications TC: 2.A.1.2 [The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID
      51  NESNFDMVPY SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF
     101  NITEELANVT IVVYFIFQGV APSIMGGLAD TFGRRPIVLW AILAYFCACI
     151  GLACAHNYAQ ILALRCLQAA GISPVIAINS GIMGDVTTKV ERGGYVGLVA
     201  GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF STLLMPETKR
     251  TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP
     301  LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL
     351  PAGISTLTSI ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV
     401  AELIHSNSHY AFNLVEARLH PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL
     451  CTSAFASLFS NCILTFSTTL IVDLFPSKAS TATGCLNLFR CLLSAIFIAA
     501  LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF DRIRANDKSA
     551  GRSVGKNSEK VST*

external links for Qdr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Qdr1p
1) Nunes PA, et al.  (2001) Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance. Antimicrob Agents Chemother 45(5):1528-34
2) Vargas RC, et al.  (2004) Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant. Antimicrob Agents Chemother 48(7):2531-7
3) Tenreiro S, et al.  (2005) The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Biochem Biophys Res Commun 327(3):952-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Dias PJ, et al.  (2010) Evolution of the 12-Spanner Drug:H+ Antiporter DHA1 Family in Hemiascomycetous Yeasts. OMICS 14(6):701-10