HIS5/YIL116W Protein Information

Standard Name	His5p 1
Systematic Name	Yil116wp
ORF Classification	Verified
Description	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts (1, 2, 3, 4)
Name Description	HIStidine requiring 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	385
Molecular Weight (Da)	42,646
Isoelectric Point (pI)	6.37

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with His5p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012C8A9 \| P07172 MIPS: YIL116W NCBI: 3788 \| 553132 \| 558690 \| 6322075 \| 729721 \| NP_012150.1 GenBank/EMBL/DDBJ: DAA08437.1 \| M38613 \| X05650 \| Z38125
External Classifications	EC: 2.6.1.9 [Histidinol-phosphate transaminase]

Amino Acid Sequence (or in FASTA format)
1 MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN 51 LHRYPDPHQL EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI 101 DAIIRACCVP GKEKILVLPP TYSMYSVCAN INDIEVVQCP LTVSDGSFQM 151 DTEAVLTILK NDSLIKLMFV TSPGNPTGAK IKTSLIEKVL QNWDNGLVVV 201 DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG MTYATAELAR 251 ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT 301 ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN 351 ELGCSGCLRI TVGTHEENTH LIKYFKETLY KLANE*

Amino Acid Sequence (or in FASTA format)

       1  MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN
      51  LHRYPDPHQL EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI
     101  DAIIRACCVP GKEKILVLPP TYSMYSVCAN INDIEVVQCP LTVSDGSFQM
     151  DTEAVLTILK NDSLIKLMFV TSPGNPTGAK IKTSLIEKVL QNWDNGLVVV
     201  DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG MTYATAELAR
     251  ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT
     301  ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN
     351  ELGCSGCLRI TVGTHEENTH LIKYFKETLY KLANE*

external links for His5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for His5p

1)	Harashima S, et al. (1981) Cloning of the HIS5 gene of Saccharomyces cerevisiae by yeast transformation. Gene 16(1-3):335-41
2)	Pearce DA and Sherman F (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
3)	Alifano P, et al. (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69
4)	Fink GR (1964) GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. Science 146(3643):525-7