HIS5/YIL116W Protein Information Help

Standard Name His5p 1
Systematic Name Yil116wp
ORF Classification Verified
Description Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts (1, 2, 3, 4)
Name Description HIStidine requiring 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 385
Molecular Weight (Da) 42,646
Isoelectric Point (pI) 6.37

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with His5p (InterPro)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012C8A9 | P07172
MIPS: YIL116W
NCBI: 3788 | 553132 | 558690 | 6322075 | 729721 | NP_012150.1 | NM_001179464.1
GenBank/EMBL/DDBJ: AAA34675.1 | CAA29139.1 | CAA86264.1 | DAA08437.1 | M38613 | X05650 | Z38125
External Classifications EC: 2.6.1.9 [Histidinol-phosphate transaminase]
Amino Acid Sequence (or in FASTA format)
       1  MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN
      51  LHRYPDPHQL EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI
     101  DAIIRACCVP GKEKILVLPP TYSMYSVCAN INDIEVVQCP LTVSDGSFQM
     151  DTEAVLTILK NDSLIKLMFV TSPGNPTGAK IKTSLIEKVL QNWDNGLVVV
     201  DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG MTYATAELAR
     251  ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT
     301  ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN
     351  ELGCSGCLRI TVGTHEENTH LIKYFKETLY KLANE*               

external links for His5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY GeneMANIA YeastRC Structure Prediction (Seattle)

IMP

References cited on this page View Complete Literature Guide for His5p
1) Harashima S, et al.  (1981) Cloning of the HIS5 gene of Saccharomyces cerevisiae by yeast transformation. Gene 16(1-3):335-41
2) Pearce DA and Sherman F  (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
3) Alifano P, et al.  (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69
4) Fink GR  (1964) GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. Science 146(3643):525-7