COX5B/YIL111W Protein Information Help

Standard Name Cox5bp
Systematic Name Yil111wp
ORF Classification Verified
Description Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication (1, 2)
Name Description Cytochrome c OXidase
Experimental Data
Molecules/cell 2250 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 151
Molecular Weight (Da) 17,197
Isoelectric Point (pI) 10.62

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cox5bp (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001287A5 | P00425
MIPS: YIL111W
NCBI: 117106 | 171291 | 171293 | 558695 | 6322080 | NP_012155.1
GenBank/EMBL/DDBJ: DAA08442.1 | M11140 | M17799 | Z38125
External Classifications EC: 1.9.3.1 [Cytochrome-c oxidase]
Amino Acid Sequence (or in FASTA format)
 
       1  MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL
      51  TERQKLPWKT LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL
     101  GISFGLFGLV RLLANPETPK TMNREWQLKS DEYLKSKNAN PWGGYSQVQS
     151  K*

external links for Cox5bp
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cox5bp
1) Hodge MR, et al.  (1989) Inverse regulation of the yeast COX5 genes by oxygen and heme. Mol Cell Biol 9(5):1958-64
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41