HPM1/YIL110W Protein Information

Standard Name	Hpm1p 1
Systematic Name	Yil110wp
Alias	Mni1p 2
ORF Classification	Verified
Description	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance (1, 3, 4, 5)
Name Description	Histidine Protein Methyltransferase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	377
Molecular Weight (Da)	42,514
Isoelectric Point (pI)	4.38

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hpm1p (InterPro)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B433 \| P40481 MIPS: YIL110W NCBI: 45270042 \| 558696 \| 6322081 \| 731858 \| NP_012156.1 GenBank/EMBL/DDBJ: DAA08443.1 \| AY558076 \| Z38125
External Classifications	EC: 2.1.1.85 [Protein-histidine N-methyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG 51 VVQPNVEDLG TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE 101 TDAQSNNNST ELDILLGDTS EDLRKNIYEG GLKSWECSYD LVDLLSENVD 151 RISNDIDAVV EIGCGTALPS EFLFRSALLR NDRSKGLKFV LTDYNASVLR 201 LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DIPINNEELL LTSKLLAAFY 251 DDVQSRNISV TLISGSWGRK FSNLIHEVLS GSQKVLSLSS ETIYQPDNLP 301 VIAETILDIH NLPQTDVKTY VAAKDIYFGV GGSITEFEAY LDDKINSEHL 351 PIHSERFKVN SGLKRSIICI ETNKAIR*

Amino Acid Sequence (or in FASTA format)

       1  MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG
      51  VVQPNVEDLG TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE
     101  TDAQSNNNST ELDILLGDTS EDLRKNIYEG GLKSWECSYD LVDLLSENVD
     151  RISNDIDAVV EIGCGTALPS EFLFRSALLR NDRSKGLKFV LTDYNASVLR
     201  LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DIPINNEELL LTSKLLAAFY
     251  DDVQSRNISV TLISGSWGRK FSNLIHEVLS GSQKVLSLSS ETIYQPDNLP
     301  VIAETILDIH NLPQTDVKTY VAAKDIYFGV GGSITEFEAY LDDKINSEHL
     351  PIHSERFKVN SGLKRSIICI ETNKAIR*

external links for Hpm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Hpm1p

1)	Webb KJ, et al. (2010) A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase. J Biol Chem 285(48):37598-606
2)	Bengtsson O, et al. (2008) Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Yeast 25(11):835-47
3)	Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
4)	Katz JE, et al. (2003) Automated identification of putative methyltransferases from genomic open reading frames. Mol Cell Proteomics 2(8):525-40
5)	Lesage G, et al. (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49