PFK26/YIL107C Protein Information Help

Standard Name Pfk26p 1
Systematic Name Yil107cp
ORF Classification Verified
Description 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A (2, 3, 4)
Name Description 6-PhosphoFructo-2-Kinase 1
Gene Product PFK-2 , PFK2
Experimental Data
Molecules/cell 1710 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 827
Molecular Weight (Da) 93,416
Isoelectric Point (pI) 9.29

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pfk26p (InterPro)
Physical Interactions There are 28 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000124F5B | P40433
MIPS: YIL107C
NCBI: 172136 | 51013089 | 558699 | 6322084 | 728742 | NP_012159.1 | NM_001179455.1
GenBank/EMBL/DDBJ: DAA08446.1 | AY692819 | M80801 | Z38125
External Classifications EC: 2.7.1.105 [6-phosphofructo-2-kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MFKPVDFSET SPVPPDIDLA PTQSPHHVAP SQDSSYDLLS RSSDDKIDAE
      51  KGPHDELSKH LPLFQKRPLS DTPISSNWNS PGITEENTPS DSPENSATNL
     101  KSLHRLHIND ETQLKNAKIP TNDTTDYMPP SDGANEVTRI DLKDIKSPTR
     151  HHKRRPTTID VPGLTKSKTS PDGLISKEDS GSKLVIVMVG LPATGKSFIT
     201  NKLSRFLNYS LYYCKVFNVG NTRRKFAKEH GLKDQDSKFF EPKNADSTRL
     251  RDKWAMDTLD ELLDYLLEGS GSVGIFDATN TSRERRKNVL ARIRKRSPHL
     301  KVLFLESVCS DHALVQKNIR LKLFGPDYKG KDPESSLKDF KSRLANYLKA
     351  YEPIEDDENL QYIKMIDVGK KVIAYNIQGF LASQTVYYLL NFNLADRQIW
     401  ITRSGESEDN VSGRIGGNSH LTPRGLRFAK SLPKFIARQR EIFYQNLMQQ
     451  KKNNENTDGN IYNDFFVWTS MRARTIGTAQ YFNEDDYPIK QMKMLDELSA
     501  GDYDGMTYPE IKNNFPEEFE KRQKDKLRYR YPGIGGESYM DVINRLRPVI
     551  TELERIEDNV LIITHRVVAR ALLGYFMNLS MGIIANLDVP LHCVYCLEPK
     601  PYGITWSLWE YDEASDSFSK VPQTDLNTTR VKEVGLVYNE RRYSVIPTAP
     651  PSARSSFASD FLSRKRSNPT SASSSQSELS EQPKNSVSAQ TGSNNTTLIG
     701  SNFNIKNENG DSRIPLSAPL MATNTSNNIL DGGGTSISIH RPRVVPNQNN
     751  VNPLLANNNK AASNVPNVKK SAATPRQIFE IDKVDEKLSM LKNKSFLLHG
     801  KDYPNNADNN DNEDIRAKTM NRSQSHV*

external links for Pfk26p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY


References cited on this page View Complete Literature Guide for Pfk26p
1) Kretschmer M and Fraenkel DG  (1991) Yeast 6-phosphofructo-2-kinase: sequence and mutant. Biochemistry 30(44):10663-72
2) Goncalves PM, et al.  (1997) Signalling pathways leading to transcriptional regulation of genes involved in the activation of glycolysis in yeast. Mol Microbiol 25(3):483-93
3) Kretschmer M, et al.  (1993) Mutation of monofunctional 6-phosphofructo-2-kinase in yeast to bifunctional 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase. Biochemistry 32(41):11143-8
4) Bedri A, et al.  (1989) Kinetics of 6-phosphofructo-2-kinase from Saccharomyces cerevisiae: inhibition of the enzyme by ATP. Biomed Biochim Acta 48(7):403-11
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41