LYS12/YIL094C Protein Information Help

Standard Name Lys12p 1
Systematic Name Yil094cp
Alias Lys10p , Lys11p
ORF Classification Verified
Description Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate (2)
Name Description LYSine requiring 1
Experimental Data
Molecules/cell 19100 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 371
Molecular Weight (Da) 40,069
Isoelectric Point (pI) 8.06

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Lys12p (InterPro)
Physical Interactions There are 60 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052EE6 | P40495
MIPS: YIL094C
NCBI: 577120 | 6322097 | 731845 | NP_012172.1 | NM_001179442.1
GenBank/EMBL/DDBJ: DAA08459.1 | Z46728
External Classifications EC: 1.1.1.87 [Homoisocitrate dehydrogenase]
Amino Acid Sequence (or in FASTA format)
 
       1  MFRSVATRLS ACRGLASNAA RKSLTIGLIP GDGIGKEVIP AGKQVLENLN
      51  SKHGLSFNFI DLYAGFQTFQ ETGKALPDET VKVLKEQCQG ALFGAVQSPT
     101  TKVEGYSSPI VALRREMGLF ANVRPVKSVE GEKGKPIDMV IVRENTEDLY
     151  IKIEKTYIDK ATGTRVADAT KRISEIATRR IATIALDIAL KRLQTRGQAT
     201  LTVTHKSNVL SQSDGLFREI CKEVYESNKD KYGQIKYNEQ IVDSMVYRLF
     251  REPQCFDVIV APNLYGDILS DGAAALVGSL GVVPSANVGP EIVIGEPCHG
     301  SAPDIAGKGI ANPIATIRST ALMLEFLGHN EAAQDIYKAV DANLREGSIK
     351  TPDLGGKAST QQVVDDVLSR L*

external links for Lys12p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Lys12p
1) Jonkers, H., et al.  (1998) Identification of YIL094C as the gene for homo-isocitrate dehydrogenase (LYS12) in Saccharomyces cerevisiae
2) Strassman M and Ceci LN  (1965) Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid. J Biol Chem 240(11):4357-61
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41