SDS3/YIL084C Protein Information

Standard Name	Sds3p 1
Systematic Name	Yil084cp
ORF Classification	Verified
Description	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes (2, 3, 4)
Name Description	Suppressor of Defective Silencing 5

Experimental Data
Molecules/cell	105 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	327
Molecular Weight (Da)	37,625
Isoelectric Point (pI)	9.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sds3p (InterPro)
Physical Interactions	There are 72 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053139 \| P40505 MIPS: YIL084C NCBI: 1480732 \| 51013209 \| 577130 \| 6322107 \| 731835 \| NP_012182.1 GenBank/EMBL/DDBJ: DAA08468.1 \| AY692879 \| U62525 \| Z46728

Amino Acid Sequence (or in FASTA format)
1 MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD 51 LTSLHQGDNG QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE 101 KAKAEHEKLI KLCKERLYSS IEQKIKKLQE ERLLMDVANV HSYAMNYSRP 151 QYQKNTRSHT VSGWDSSSNE YGRDTANESA TDTGAGNDRR TLRRRNASKD 201 TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY KSGMNSDSDF 251 LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK 301 PDEVTEDISL IRELTGQPPA PFRLRSD*

Amino Acid Sequence (or in FASTA format)

       1  MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD
      51  LTSLHQGDNG QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE
     101  KAKAEHEKLI KLCKERLYSS IEQKIKKLQE ERLLMDVANV HSYAMNYSRP
     151  QYQKNTRSHT VSGWDSSSNE YGRDTANESA TDTGAGNDRR TLRRRNASKD
     201  TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY KSGMNSDSDF
     251  LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK
     301  PDEVTEDISL IRELTGQPPA PFRLRSD*

external links for Sds3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sds3p

1)	Sussel L, et al. (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
2)	Vannier D, et al. (1996) Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Genetics 144(4):1343-53
3)	Vannier D, et al. (2001) A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae. Mol Genet Genomics 265(3):560-8
4)	Lechner T, et al. (2000) Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. J Biol Chem 275(52):40961-6
5)	Sussel L, et al. (1993) Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol 13(7):3919-28
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41