SEE1/YIL064W Protein Information

Standard Name	See1p 1
Systematic Name	Yil064wp
ORF Classification	Verified
Description	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport (1, 2, 3, 4)
Name Description	Secretion and Early Endocytosis 1

Experimental Data
Molecules/cell	1620 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	257
Molecular Weight (Da)	28,689
Isoelectric Point (pI)	4.79

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with See1p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B3E0 \| P40516 MIPS: YIL064W NCBI: 51012781 \| 557805 \| 6322125 \| 731822 \| NP_012200.1 \| NM_001179414.1 GenBank/EMBL/DDBJ: DAA08486.1 \| AY692665 \| Z38060
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MKRSEKKSMS SALKNGIMER TQPEKVVQMQ GTADLSTSKL GTKKYWDELY 51 ALELENFRRN PQDTGDCWFS DSDAEQKMID FLVDNIGAYR ISENASVVDL 101 GTGNGHMLFE LHQTEFQGKL VGIDYSEESV KLASNIAEAT GVDNFISFQQ 151 ADIFSGDWKP GKYDIVLDKG TLDAISLSGM KINGKLDVVD VYAGVVERIL 201 KKDGIFLITS CNFTQDELVK IIETDNLKMW KTIKYPVFQF GGVQGATICS 251 VAFVKQN*

Amino Acid Sequence (or in FASTA format)

       1  MKRSEKKSMS SALKNGIMER TQPEKVVQMQ GTADLSTSKL GTKKYWDELY
      51  ALELENFRRN PQDTGDCWFS DSDAEQKMID FLVDNIGAYR ISENASVVDL
     101  GTGNGHMLFE LHQTEFQGKL VGIDYSEESV KLASNIAEAT GVDNFISFQQ
     151  ADIFSGDWKP GKYDIVLDKG TLDAISLSGM KINGKLDVVD VYAGVVERIL
     201  KKDGIFLITS CNFTQDELVK IIETDNLKMW KTIKYPVFQF GGVQGATICS
     251  VAFVKQN*

external links for See1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for See1p

1)	Martin-Granados C, et al. (2008) Absence of See1p, a widely conserved Saccharomyces cerevisiae protein, confers both deficient heterologous protein production and endocytosis. Yeast 25(12):871-7
2)	Katz JE, et al. (2003) Automated identification of putative methyltransferases from genomic open reading frames. Mol Cell Proteomics 2(8):525-40
3)	Lipson RS, et al. (2010) Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Arch Biochem Biophys 500(2):137-143
4)	Couttas TA, et al. (2012) Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Proteomics 12(7):960-72
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41