MMF1/YIL051C Protein Information Help

Standard Name Mmf1p 1
Systematic Name Yil051cp
Alias Ibm1p
ORF Classification Verified
Description Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Mitochondrial Matrix Factor 1
Experimental Data
Molecules/cell 168000 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 145
Molecular Weight (Da) 15,908
Isoelectric Point (pI) 10.06

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mmf1p (InterPro)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 30 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F26A | P40185
MIPS: YIL051C
NCBI: 12082318 | 335892424 | 398364411 | 45270492 | 557817 | 731809 | NP_012213.3
GenBank/EMBL/DDBJ: DAA08496.1 | AB050474 | AY558301 | Z38060
Amino Acid Sequence (or in FASTA format)
 
       1  MFLRNSVLRT APVLRRGITT LTPVSTKLAP PAAASYSQAM KANNFVYVSG
      51  QIPYTPDNKP VQGSISEKAE QVFQNVKNIL AESNSSLDNI VKVNVFLADM
     101  KNFAEFNSVY AKHFHTHKPA RSCVGVASLP LNVDLEMEVI AVEKN*

external links for Mmf1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mmf1p
1) Oxelmark E, et al.  (2000) Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Mol Cell Biol 20(20):7784-97
2) Kim JM, et al.  (2001) A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Genes Cells 6(6):507-17
3) Accardi R, et al.  (2004) High levels of the mitochondrial large ribosomal subunit protein 40 prevent loss of mitochondrial DNA in null mmf1 Saccharomyces cerevisiae cells. Yeast 21(7):539-48
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41