DFG10/YIL049W Protein Information

Standard Name	Dfg10p 1
Systematic Name	Yil049wp
ORF Classification	Verified
Description	Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation) (1, 2)
Name Description	Defective for Filamentous Growth 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	253
Molecular Weight (Da)	30,305
Isoelectric Point (pI)	9.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dfg10p (InterPro)
Transmembrane Domains	There are 4 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001291EC \| P40526 MIPS: YIL049W NCBI: 557819 \| 6322140 \| 731807 \| NP_012215.1 GenBank/EMBL/DDBJ: DAA08498.1 \| Z38060

Amino Acid Sequence (or in FASTA format)
1 MYFDEEQLLK YTIYAYRLSF FVGICSLFIA KSCLPEFLQY GKTYRPKENS 51 KYSSILERIK KFTVPKAYFS HFYYLATFLS LVTLYFYPKF PIVWIIFGHS 101 LRRLYETLYV LHYTSNSRMN WSHYLVGIWF YSVLLLILNI SLYKNSIPNT 151 LNMNAFIIFC IASWDQYKNH VILANLVKYS LPTGRLFRLV CCPHYLDEII 201 IYSTLLPYEQ EFYLTLVWVI TSLTISALET KNYYRHKFKD NHVAPYAIIP 251 FII*

Amino Acid Sequence (or in FASTA format)

       1  MYFDEEQLLK YTIYAYRLSF FVGICSLFIA KSCLPEFLQY GKTYRPKENS
      51  KYSSILERIK KFTVPKAYFS HFYYLATFLS LVTLYFYPKF PIVWIIFGHS
     101  LRRLYETLYV LHYTSNSRMN WSHYLVGIWF YSVLLLILNI SLYKNSIPNT
     151  LNMNAFIIFC IASWDQYKNH VILANLVKYS LPTGRLFRLV CCPHYLDEII
     201  IYSTLLPYEQ EFYLTLVWVI TSLTISALET KNYYRHKFKD NHVAPYAIIP
     251  FII*

external links for Dfg10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Dfg10p

1)	Mosch HU and Fink GR (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145(3):671-84
2)	Cantagrel V, et al. (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2):203-17