TED1/YIL039W Protein Information

Standard Name	Ted1p 1
Systematic Name	Yil039wp
ORF Classification	Verified
Description	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) (1, 2)
Name Description	Trafficking of Emp24p/Erv25p-dependent cargo Disrupted 1

Experimental Data
Molecules/cell	1070 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	473
Molecular Weight (Da)	54,927
Isoelectric Point (pI)	5.58

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ted1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B3A4 \| P40533 MIPS: YIL039W NCBI: 600009 \| 6322150 \| 731799 \| NP_012225.1 GenBank/EMBL/DDBJ: DAA08509.1 \| Z46861

Amino Acid Sequence (or in FASTA format)
1 MLRCAVKKFA YFATFLTIVA NIYIYTYPSF HPEQCSWNCS NKNAPLQKDL 51 TFVDKVKNYF SDVREQWHGS HASAGNDEDI HILAFGDPQI KGIWPKTPYV 101 SRLDTYGNDY YLGHIYDMMQ QRLKPQVVTV MGDLFSSQWI GDSEFHNRTK 151 RYISRIFKRD PTSIENIKQQ NLDEKGQYKA NWPEWGDRFN EILDNVKENE 201 ADNQELSFGF GYENIHSWNP DLEDFLIINI TGNHDVGYSG DATYQHMTRF 251 HDLFGKDNYW IEYETNTTHP WRIVVLNDLL LEGPALQPEF VEATWIFLNQ 301 LNERKFNGST VLLTHVPFYK REGLCVDGPD TRYYPDAHAP ESYKSGLLRS 351 QNHLSESVSN QVLNMIFENG KPGIILTGHD HEGCETVYNK KSTSTWEATK 401 NIESDVFVKE ITVKSMMGEF NGNTGLVTGH FNTDSMTWEW TFSLCPFAIQ 451 HVWWFAKVSL LVTIFTWSSL LFV*

Amino Acid Sequence (or in FASTA format)

       1  MLRCAVKKFA YFATFLTIVA NIYIYTYPSF HPEQCSWNCS NKNAPLQKDL
      51  TFVDKVKNYF SDVREQWHGS HASAGNDEDI HILAFGDPQI KGIWPKTPYV
     101  SRLDTYGNDY YLGHIYDMMQ QRLKPQVVTV MGDLFSSQWI GDSEFHNRTK
     151  RYISRIFKRD PTSIENIKQQ NLDEKGQYKA NWPEWGDRFN EILDNVKENE
     201  ADNQELSFGF GYENIHSWNP DLEDFLIINI TGNHDVGYSG DATYQHMTRF
     251  HDLFGKDNYW IEYETNTTHP WRIVVLNDLL LEGPALQPEF VEATWIFLNQ
     301  LNERKFNGST VLLTHVPFYK REGLCVDGPD TRYYPDAHAP ESYKSGLLRS
     351  QNHLSESVSN QVLNMIFENG KPGIILTGHD HEGCETVYNK KSTSTWEATK
     401  NIESDVFVKE ITVKSMMGEF NGNTGLVTGH FNTDSMTWEW TFSLCPFAIQ
     451  HVWWFAKVSL LVTIFTWSSL LFV*

external links for Ted1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ted1p

1)	Haass FA, et al. (2007) Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A 104(46):18079-18084
2)	Dilda PJ, et al. (2005) Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. J Natl Cancer Inst 97(20):1539-47
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41