BCY1/YIL033C Protein Information

Standard Name	Bcy1p
Systematic Name	Yil033cp
Alias	Sra1p
ORF Classification	Verified
Description	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation (1, 2)
Name Description	Bypass of CYclase mutations 3

Experimental Data
Molecules/cell	4280 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	416
Molecular Weight (Da)	47,219
Isoelectric Point (pI)	8.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bcy1p (InterPro)
Physical Interactions	There are 71 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E93 \| P07278 MIPS: YIL033C NCBI: 125222 \| 171159 \| 172689 \| 313103903 \| 4303 \| 45270064 \| 600015 \| 6322156 \| NP_012231.1 GenBank/EMBL/DDBJ: DAA08515.1 \| AY558087 \| M15756 \| M17223 \| X05051 \| Z46861

Amino Acid Sequence (or in FASTA format)
1 MVSSLPKESQ AELQLFQNEI NAANPSDFLQ FSANYFNKRL EQQRAFLKAR 51 EPEFKAKNIV LFPEPEESFS RPQSAQSQSR SRSSVMFKSP FVNEDPHSNV 101 FKSGFNLDPH EQDTHQQAQE EQQHTREKTS TPPLPMHFNA QRRTSVSGET 151 LQPNNFDDWT PDHYKEKSEQ QLQRLEKSIR NNFLFNKLDS DSKRLVINCL 201 EEKSVPKGAT IIKQGDQGDY FYVVEKGTVD FYVNDNKVNS SGPGSSFGEL 251 ALMYNSPRAA TVVATSDCLL WALDRLTFRK ILLGSSFKKR LMYDDLLKSM 301 PVLKSLTTYD RAKLADALDT KIYQPGETII REGDQGENFY LIEYGAVDVS 351 KKGQGVINKL KDHDYFGEVA LLNDLPRQAT VTATKRTKVA TLGKSGFQRL 401 LGPAVDVLKL NDPTRH*

Amino Acid Sequence (or in FASTA format)

       1  MVSSLPKESQ AELQLFQNEI NAANPSDFLQ FSANYFNKRL EQQRAFLKAR
      51  EPEFKAKNIV LFPEPEESFS RPQSAQSQSR SRSSVMFKSP FVNEDPHSNV
     101  FKSGFNLDPH EQDTHQQAQE EQQHTREKTS TPPLPMHFNA QRRTSVSGET
     151  LQPNNFDDWT PDHYKEKSEQ QLQRLEKSIR NNFLFNKLDS DSKRLVINCL
     201  EEKSVPKGAT IIKQGDQGDY FYVVEKGTVD FYVNDNKVNS SGPGSSFGEL
     251  ALMYNSPRAA TVVATSDCLL WALDRLTFRK ILLGSSFKKR LMYDDLLKSM
     301  PVLKSLTTYD RAKLADALDT KIYQPGETII REGDQGENFY LIEYGAVDVS
     351  KKGQGVINKL KDHDYFGEVA LLNDLPRQAT VTATKRTKVA TLGKSGFQRL
     401  LGPAVDVLKL NDPTRH*

external links for Bcy1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Bcy1p

1)	Toda T, et al. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7(4):1371-7
2)	Cannon JF, et al. (1990) Yeast cAMP-dependent protein kinase regulatory subunit mutations display a variety of phenotypes. J Biol Chem 265(20):11897-904
3)	Matsumoto K, et al. (1982) Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 79(7):2355-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41