IRR1/YIL026C Protein Information Help

Standard Name Irr1p
Systematic Name Yil026cp
Alias Scc3p 1
ORF Classification Verified
Description Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability (1, 2)
Name Description IRRegular 3
Experimental Data
Molecules/cell 4090 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,150
Molecular Weight (Da) 133,007
Isoelectric Point (pI) 4.84

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Irr1p (InterPro)
Physical Interactions There are 46 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530AE | P40541
MIPS: YIL026C
NCBI: 599973 | 619595 | 6322163 | 731791 | NP_012238.1
GenBank/EMBL/DDBJ: DAA08520.1 | U17918 | Z46881
Amino Acid Sequence (or in FASTA format)
 
       1  MTAVRRSTRI RTKSQVIEED YDDEQNTSAQ HVESDKITAK TQHEEEEEQD
      51  TGESEESSSE DDYEDQDDDD YVDTATAKRK SRKRKPKSAS NTSSKRQKKK
     101  PTSAQKSAVS HAPAYHRSKK DQDQYLEIAK DFQPTELFDI LSTSEDVSIE
     151  ELLREWLETY SENRDKFLQE FINLLLNCCG SVARVEDHDV HSNESSNETI
     201  GEIQLLFQRQ KLHEFYLLIS KENKKRKNFK MGPLYQNFAE FMTKLLEVAN
     251  DLQLLYVESD EDDTQIVTGN LVLDLLTWLS SFSVCKIRCF RYISTLTLYL
     301  FQDYLTQQAV NLEKNYLAKL SKQLSLEEKK KRPNNKTLEK LESTIAETQG
     351  SKVVIDSIID NIVKLCFVHR YKDVSDLIRS ESMLHLSIWI KNYPEYFLKV
     401  TFLKYFGWLL SDNSVSVRLQ VTKILPHLII QNHNSKSTDN SAIRQVFERF
     451  KTKILEVAIR DVNLDVRIHS IQVLTEASSL GYLDDSEILI ISSLMFDEEF
     501  DPFKTSSFNK RSKFLSTVAK FLARVIKEKF DEFIKTHEDL PKEVDGLEVG
     551  PVVQVGIFIK ILNDSLIYHL KDCAEVDSRT KIRMLTQAAE FLSPYISTHL
     601  KTICNLLISD TESNELIQKL QNSANNNSDD EDVDDEELDI TPLFPIDRNS
     651  TILYLNVFHG LCAGANNPKI QTKDSVKEIV LPLFYDLLNA ASIESADILC
     701  PLLESFITFS LDDWISIGYE TELKKITDKT IKAFMDSTIG NSKVDMKYDI
     751  FAKFIHHIHH FEKKELQEKF LNQIATLKIH LKKFLQEKMD PNNSRDDYKD
     801  LTCSLYELYI NKLTILGRDY PIEVDEELLQ LFLNNFVSRI PIMFQDFDDS
     851  TAQEINFKML VLLATWNLEK WREIIEKVRD YENSISKDLR SVWKPIAAII
     901  GRLNTLVISL AATNETFENI NSLFYLKWSA CTSLMDIIVA IKIFELKLPA
     951  DATTWRYSMS EQFPFYLHDN ASKVLLKIFL YLESLFAKQV DVQLERVADE
    1001  DANLNDLPET GFFENIETEF LLFTVKLKGL MKLNILDERF ASRVALNKEK
    1051  LGPLFKKIVD DTIMENPEPN KKNIQKAKSN QTQREKAPLQ PNSERETDHA
    1101  NTENNDPDIP MTIDLEPIEE SSQNNSELAP IEEHPTVVDA IDNSDEITQD
    1151  *

external links for Irr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
YGOB CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Irr1p
1) Toth A, et al.  (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33
2) Kurlandzka A, et al.  (1995) A new essential gene located on Saccharomyces cerevisiae chromosome IX. Yeast 11(9):885-90
3) Kurlandzka A, et al.  (1999) Saccharomyces cerevisiae IRR1 protein is indirectly involved in colony formation. Yeast 15(1):23-33
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41