PDR11/YIL013C Protein Information Help

Standard Name Pdr11p
Systematic Name Yil013cp
ORF Classification Verified
Description ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Pleiotropic Drug Resistance
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,411
Molecular Weight (Da) 160,536
Isoelectric Point (pI) 6.84

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pdr11p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000168353 | P40550
MIPS: YIL013C
NCBI: 558389 | 599987 | 6322177 | 731781 | NP_012252.1 | NM_001179363.1
GenBank/EMBL/DDBJ: CAA86236.1 | CAA86980.1 | DAA08533.1 | Z38113 | Z46881
External Classifications TC: 3.A.1.205 [The Pleiotropic Drug Resistance (PDR) Family]
Amino Acid Sequence (or in FASTA format)
       1  MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS
      51  DITFRANEGE VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ
     101  FASKCPHQII YNNEQDIHFP YLTVEQTIDF ALSCKFHIPK QERIEMRDEL
     151  LKEFGLSHVK KTYVGNDYVR GVSGGERKRI SIIETFIANG SVYLWDNSTK
     201  GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF DKILMLGDSF
     251  QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL
     301  DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV
     351  NPDDISPIFS IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG
     401  SLFYNIPLTT IGSFSRGSLT FFSILFFTFL SLADMPASFQ RQPVVRKHVQ
     451  LHFYYNWVET LATNFFDCCS KFILVVIFTI ILYFLAHLQY NAARFFIFLL
     501  FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY ASYVIYMKDM
     551  HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH
     601  KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS
     651  LLAAEYITPL FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP
     701  KTPIANFSTS SSSVPSVSHQ YDTDYNIKHP DETVNNHTKE SVAMETQKHV
     751  ISWKNINYTI GDKKLINDAS GYISSGLTAL MGESGAGKTT LLNVLSQRTE
     801  SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV RESLEISCVL
     851  RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF
     901  LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL
     951  LKRGGECVYF GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN
    1001  IPMDDAEKPT SSKIDEPVSY HKQSDSINWA ELWQSSPEKV RVADDLLLLE
    1051  EEARKSGVDF TTSVWSPPSY MEQIKLITKR QYICTKRDMT YVFAKYALNA
    1101  GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ VQDKALQSKE
    1151  VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA
    1201  RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG
    1251  VMQPYSLFPR FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP
    1301  VMGQTCGQFM KPFIDEFGGK LHINNTYTVC AYCMYTVGDD FLAQENMSYH
    1351  HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK KIWPSVIDGI KKCIPSMRRS
    1401  KTSHNPNEQS V*                                         

external links for Pdr11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains

DIP TCDB

GeneMANIA YeastRC Structure Prediction (Seattle)

IMP

References cited on this page View Complete Literature Guide for Pdr11p
1) Balzi E and Goffeau A  (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6
2) Rogers B, et al.  (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
3) Wilcox LJ, et al.  (2002) Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem 277(36):32466-72
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61