PDR11/YIL013C Protein Information

Standard Name	Pdr11p
Systematic Name	Yil013cp
ORF Classification	Verified
Description	ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Pleiotropic Drug Resistance

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,411
Molecular Weight (Da)	160,536
Isoelectric Point (pI)	6.84

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pdr11p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168353 \| P40550 MIPS: YIL013C NCBI: 558389 \| 599987 \| 6322177 \| 731781 \| NP_012252.1 GenBank/EMBL/DDBJ: DAA08533.1 \| Z38113 \| Z46881
External Classifications	TC: 3.A.1.205 [The Pleiotropic Drug Resistance (PDR) Family]

Amino Acid Sequence (or in FASTA format)
1 MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS 51 DITFRANEGE VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ 101 FASKCPHQII YNNEQDIHFP YLTVEQTIDF ALSCKFHIPK QERIEMRDEL 151 LKEFGLSHVK KTYVGNDYVR GVSGGERKRI SIIETFIANG SVYLWDNSTK 201 GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF DKILMLGDSF 251 QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL 301 DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV 351 NPDDISPIFS IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG 401 SLFYNIPLTT IGSFSRGSLT FFSILFFTFL SLADMPASFQ RQPVVRKHVQ 451 LHFYYNWVET LATNFFDCCS KFILVVIFTI ILYFLAHLQY NAARFFIFLL 501 FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY ASYVIYMKDM 551 HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH 601 KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS 651 LLAAEYITPL FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP 701 KTPIANFSTS SSSVPSVSHQ YDTDYNIKHP DETVNNHTKE SVAMETQKHV 751 ISWKNINYTI GDKKLINDAS GYISSGLTAL MGESGAGKTT LLNVLSQRTE 801 SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV RESLEISCVL 851 RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF 901 LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL 951 LKRGGECVYF GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN 1001 IPMDDAEKPT SSKIDEPVSY HKQSDSINWA ELWQSSPEKV RVADDLLLLE 1051 EEARKSGVDF TTSVWSPPSY MEQIKLITKR QYICTKRDMT YVFAKYALNA 1101 GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ VQDKALQSKE 1151 VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA 1201 RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG 1251 VMQPYSLFPR FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP 1301 VMGQTCGQFM KPFIDEFGGK LHINNTYTVC AYCMYTVGDD FLAQENMSYH 1351 HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK KIWPSVIDGI KKCIPSMRRS 1401 KTSHNPNEQS V*

Amino Acid Sequence (or in FASTA format)

       1  MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS
      51  DITFRANEGE VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ
     101  FASKCPHQII YNNEQDIHFP YLTVEQTIDF ALSCKFHIPK QERIEMRDEL
     151  LKEFGLSHVK KTYVGNDYVR GVSGGERKRI SIIETFIANG SVYLWDNSTK
     201  GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF DKILMLGDSF
     251  QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL
     301  DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV
     351  NPDDISPIFS IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG
     401  SLFYNIPLTT IGSFSRGSLT FFSILFFTFL SLADMPASFQ RQPVVRKHVQ
     451  LHFYYNWVET LATNFFDCCS KFILVVIFTI ILYFLAHLQY NAARFFIFLL
     501  FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY ASYVIYMKDM
     551  HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH
     601  KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS
     651  LLAAEYITPL FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP
     701  KTPIANFSTS SSSVPSVSHQ YDTDYNIKHP DETVNNHTKE SVAMETQKHV
     751  ISWKNINYTI GDKKLINDAS GYISSGLTAL MGESGAGKTT LLNVLSQRTE
     801  SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV RESLEISCVL
     851  RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF
     901  LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL
     951  LKRGGECVYF GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN
    1001  IPMDDAEKPT SSKIDEPVSY HKQSDSINWA ELWQSSPEKV RVADDLLLLE
    1051  EEARKSGVDF TTSVWSPPSY MEQIKLITKR QYICTKRDMT YVFAKYALNA
    1101  GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ VQDKALQSKE
    1151  VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA
    1201  RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG
    1251  VMQPYSLFPR FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP
    1301  VMGQTCGQFM KPFIDEFGGK LHINNTYTVC AYCMYTVGDD FLAQENMSYH
    1351  HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK KIWPSVIDGI KKCIPSMRRS
    1401  KTSHNPNEQS V*

external links for Pdr11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Pdr11p

1)	Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6
2)	Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
3)	Wilcox LJ, et al. (2002) Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem 277(36):32466-72
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61