TIR3/YIL011W Protein Information

Standard Name	Tir3p
Systematic Name	Yil011wp
Alias	Yib1p
ORF Classification	Verified
Description	Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication (1, 2, 3)
Name Description	TIp1-Related 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	269
Molecular Weight (Da)	26,308
Isoelectric Point (pI)	3.99

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tir3p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000136FB9 \| P40552 MIPS: YIL011W NCBI: 558391 \| 6322179 \| 731779 \| NP_012254.1 GenBank/EMBL/DDBJ: DAA08534.1 \| Z38113

Amino Acid Sequence (or in FASTA format)
1 MSFTKIAALL AVAAASTQLV SAEVGQYEIV EFDAILADVK ANLEQYMSLA 51 MNNPDFTLPS GVLDVYQHMT TATDDSYTSY FTEMDFAQIT TAMVQVPWYS 101 SRLEPEIIAA LQSAGISITS LGQTVSESGS ESATASSDAS SASESSSAAS 151 SSASESSSAA SSSASESSSA ASSSASESSS AASSSASEAA KSSSSAKSSG 201 SSAASSAASS ASSKASSAAS SSAKASSSAE KSTNSSSSAT SKNAGAAMDM 251 GFFSAGVGAA IAGAAAMLL*

Amino Acid Sequence (or in FASTA format)

       1  MSFTKIAALL AVAAASTQLV SAEVGQYEIV EFDAILADVK ANLEQYMSLA
      51  MNNPDFTLPS GVLDVYQHMT TATDDSYTSY FTEMDFAQIT TAMVQVPWYS
     101  SRLEPEIIAA LQSAGISITS LGQTVSESGS ESATASSDAS SASESSSAAS
     151  SSASESSSAA SSSASESSSA ASSSASESSS AASSSASEAA KSSSSAKSSG
     201  SSAASSAASS ASSKASSAAS SSAKASSSAE KSTNSSSSAT SKNAGAAMDM
     251  GFFSAGVGAA IAGAAAMLL*

external links for Tir3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tir3p

1)	Hamada K, et al. (1999) Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins. J Bacteriol 181(13):3886-9
2)	Abramova N, et al. (2001) Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol 183(9):2881-7
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61