DOT5/YIL010W Protein Information

Standard Name	Dot5p 1
Systematic Name	Yil010wp
ORF Classification	Verified
Description	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth (2)
Name Description	Disruptor Of Telomeric silencing 1

Experimental Data
Molecules/cell	1840 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	215
Molecular Weight (Da)	24,119
Isoelectric Point (pI)	10.13

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dot5p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001296B5 \| P40553 MIPS: YIL010W NCBI: 398364507 \| 45270486 \| 558392 \| 731778 \| 93278640 \| NP_012255.3 \| NM_001179360.3 GenBank/EMBL/DDBJ: DAA08535.1 \| AY558298 \| Z38113
External Classifications	EC: 1.11.1.15 [Peroxiredoxin]

Amino Acid Sequence (or in FASTA format)
1 MGEALRRSTR IAISKRMLEE EESKLAPIST PEVPKKKIKT GPKHNANQAV 51 VQEANRSSDV NELEIGDPIP DLSLLNEDND SISLKKITEN NRVVVFFVYP 101 RASTPGCTRQ ACGFRDNYQE LKKYAAVFGL SADSVTSQKK FQSKQNLPYH 151 LLSDPKREFI GLLGAKKTPL SGSIRSHFIF VDGKLKFKRV KISPEVSVND 201 AKKEVLEVAE KFKEE*

Amino Acid Sequence (or in FASTA format)

       1  MGEALRRSTR IAISKRMLEE EESKLAPIST PEVPKKKIKT GPKHNANQAV
      51  VQEANRSSDV NELEIGDPIP DLSLLNEDND SISLKKITEN NRVVVFFVYP
     101  RASTPGCTRQ ACGFRDNYQE LKKYAAVFGL SADSVTSQKK FQSKQNLPYH
     151  LLSDPKREFI GLLGAKKTPL SGSIRSHFIF VDGKLKFKRV KISPEVSVND
     201  AKKEVLEVAE KFKEE*

external links for Dot5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Dot5p

1)	Singer MS, et al. (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32
2)	Cha MK, et al. (2003) Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. J Biol Chem 278(27):24636-43
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41