URM1/YIL008W Protein Information 
| Standard Name | Urm1p |
|---|---|
| Systematic Name | Yil008wp |
| ORF Classification | Verified |
| Description | Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response (1, 2, 3, 4) |
| Name Description | Ubiquitin Related Modifier |
| Experimental Data | |
|---|---|
| Molecules/cell | 1240 5 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Urm1p (InterPro) |
| Physical Interactions | There are 21 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000013B361 | P40554 MIPS: YIL008W NCBI: 110590834 | 152149527 | 185177548 | 398364515 | 45270480 | 558396 | 731777 | NP_012258.3 GenBank/EMBL/DDBJ: DAA08538.1 | AY558295 | Z38113 |
external links for Urm1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| YGOB | Complexome | ||
| YOGY | DIP | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Urm1p
| 1) | Furukawa K, et al. (2000) A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes. J Biol Chem 275(11):7462-5 |
| 2) | Goehring AS, et al. (2003) Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell 14(11):4329-41 |
| 3) | Noma A, et al. (2009) Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. Nucleic Acids Res 37(4):1335-52 |
| 4) | Leidel S, et al. (2009) Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458(7235):228-32 |
| 5) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
