EPS1/YIL005W Protein Information Help

Standard Name Eps1p
Systematic Name Yil005wp
ORF Classification Verified
Description ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family (1, 2, 3)
Experimental Data
Molecules/cell 6020 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 701
Molecular Weight (Da) 81,218
Isoelectric Point (pI) 7.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Eps1p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B35F | P40557
MIPS: YIL005W
NCBI: 51830390 | 558399 | 6322186 | 731774 | NP_012261.1
GenBank/EMBL/DDBJ: DAA08541.1 | AY723829 | X79743 | Z38113
External Classifications EC: 5.3.4.1 [Protein disulfide-isomerase]
Amino Acid Sequence (or in FASTA format)
 
       1  MKMNLKRLVV TFFSCITFLL KFTIAAAEPP EGFPEPLNPT NFKEELSKGL
      51  HIIDFYSPYC PHCKHLAPVW METWEEFKEE SKTLNITFSQ VNCIESADLC
     101  GDENIEYFPE IRLYNPSGYI KSFTETPRTK ESLIAFARRE SMDPNNLDTD
     151  LDSAKSESQY LEGFDFLELI AGKATRPHLV SFWPTKDMKN SDDSLEFKNC
     201  DKCHEFQRTW KIISRQLAVD DINTGHVNCE SNPTICEELG FGDLVKITNH
     251  RADREPKVAL VLPNKTSNNL FDYPNGYSAK SDGYVDFARR TFTNSKFPNI
     301  TEGELEKKAN RDIDFLQERG RVTNNDIHLV FSYDPETVVI EDFDILEYLI
     351  EPLSKIPNIY LHQIDKNLIN LSRNLFGRMY EKINYDASQT QKVFNKEYFT
     401  MNTVTQLPTF FMFKDGDPIS YVFPGYSTTE MRNIDAIMDW VKKYSNPLVT
     451  EVDSSNLKKL ISFQTKSYSD LAIQLISSTD HKHIKGSNKL IKNLLLASWE
     501  YEHIRMENNF EEINERRARK ADGIKKIKEK KAPANKIVDK MREEIPHMDQ
     551  KKLLLGYLDI SKEKNFFRKY GITGEYKIGD VIIIDKSNNY YYNKDNFGNS
     601  LTSNNPQLLR EAFVSLNIPS KALYSSKLKG RLINSPFHNV LSFLDIIHGN
     651  GMPGYLIVIV LFIAILKGPS IYRRYKVRKH YRAKRNAVGI LGNMEKKKNQ
     701  D*

external links for Eps1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Eps1p
1) Wang Q and Chang A  (1999) Eps1, a novel PDI-related protein involved in ER quality control in yeast. EMBO J 18(21):5972-82
2) Wang Q and Chang A  (2003) Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family. EMBO J 22(15):3792-802
3) Kimura T, et al.  (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41