CRG1/YHR209W Protein Information

Standard Name	Crg1p 1
Systematic Name	Yhr209wp
ORF Classification	Verified
Description	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin (1, 2, 3, 4)
Name Description	Cantharidin Resistance Gene 1

Experimental Data
Molecules/cell	4380 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	291
Molecular Weight (Da)	33,785
Isoelectric Point (pI)	5.85

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Crg1p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B14E \| P38892 MIPS: YHR209W NCBI: 45269425 \| 458920 \| 6322003 \| 731578 \| NP_012079.1 GenBank/EMBL/DDBJ: DAA06902.1 \| AY557767 \| U00029
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MPKTSYLNKN FESAHYNNVR PSYPLSLVNE IMKFHKGTRK SLVDIGCGTG 51 KATFVVEPYF KEVIGIDPSS AMLSIAEKET NERRLDKKIR FINAPGEDLS 101 SIRPESVDMV ISAEAIHWCN LERLFQQVSS ILRSDGTFAF WFYIQPEFVD 151 FPEALNVYYK YGWSKDYMGK YLNDNQREIL LNYGGEKLRS LLSDRFGDIE 201 VTIYSPSDPN ASTVTAENSQ FLWRAAITLN QFKEFVKSWS IYTSWARDNP 251 SKPDIADIFI NELKEICHCE DLNVPLKIEW STFYYLCRKR E*

Amino Acid Sequence (or in FASTA format)

       1  MPKTSYLNKN FESAHYNNVR PSYPLSLVNE IMKFHKGTRK SLVDIGCGTG
      51  KATFVVEPYF KEVIGIDPSS AMLSIAEKET NERRLDKKIR FINAPGEDLS
     101  SIRPESVDMV ISAEAIHWCN LERLFQQVSS ILRSDGTFAF WFYIQPEFVD
     151  FPEALNVYYK YGWSKDYMGK YLNDNQREIL LNYGGEKLRS LLSDRFGDIE
     201  VTIYSPSDPN ASTVTAENSQ FLWRAAITLN QFKEFVKSWS IYTSWARDNP
     251  SKPDIADIFI NELKEICHCE DLNVPLKIEW STFYYLCRKR E*

external links for Crg1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Crg1p

1)	Hoon S, et al. (2008) An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol 4(8):498-506
2)	Niewmierzycka A and Clarke S (1999) S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. J Biol Chem 274(2):814-24
3)	Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
4)	Lissina E, et al. (2011) A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS Genet 7(10):e1002332
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41