RIX1/YHR197W Protein Information Help

Standard Name Rix1p 1
Systematic Name Yhr197wp
Alias Ipi2p 2
ORF Classification Verified
Description Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene (1, 2, 3, 4)
Name Description RIbosome eXport 1
Experimental Data
Molecules/cell 7820 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 763
Molecular Weight (Da) 86,739
Isoelectric Point (pI) 5.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rix1p (InterPro)
Physical Interactions There are 261 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000181B1EC | P38883
MIPS: YHR197W
NCBI: 341941978 | 398365005 | 458930 | 731766 | NP_012067.4
GenBank/EMBL/DDBJ: DAA06889.2 | U00030
Amino Acid Sequence (or in FASTA format)
 
       1  MSEEFIAVST LARNLEIAKG NEFHTILATL RSPVYINEQL LKSELSFLVT
      51  KILKLIRSGN DFDLWKGCHT SVVTCAYNPL VLSTHGGQLL AAIYSRLEQK
     101  TGFYSSVISS SHGKQLFNTL ISSVAIIIDL MKNKPTLSRE ALVPKLKAII
     151  PTLITLSQYE PELVLPVLQR ILKRNTTTFK PFTNKFRTVL INLIISDYAS
     201  LGTKTQRLVC ENFAYLHLLK IQVSDTSDDE TQAHHKIYAD SNWRTGLMSI
     251  LSQFKPIIQL CGEILDFEQD NELYKLIKSL PVIDESNNKE EFLPSLKLDF
     301  NAPLTLWEIP QRLSLLADML VAFISLPTPF PIRVPLGGIN SLCEVLLGVS
     351  NKYLPLKKEL RHDNELNGVI NTILPQIQFQ GIRLWEIMVS KYGKCGLSFF
     401  EGILSSIELF IPLKKKSNNE IDFNVVGSLK FEFATVFRLV NMILSHLGHQ
     451  LNIISVISQL IEVALFLSHD KTLIDSLFKN RKSIMKQQTK TKQSKRSKSA
     501  EGAFSDIYTH PELFVCKNSM NWFNEINDFF ITALNNWILP STPHIQILKY
     551  SITQSLRLKE RFGYIPESFV NLLRCEVLHP GSERVSILPI AISLLKNIND
     601  DMFELLCHPK VPVGMVYQLH KPLDLGEDGE VRDDINKKEV ETNESSSNAN
     651  TGLETLKALE NLENVTIPEP KHEVPKVVDD TAIFKKRSVE EVIERESTSS
     701  HKKVKFVEET TVDNGEELIV KKAVSQTKEE EKPMEDSEDE EQEEFEIPAI
     751  ELSDDEEEEE EEE*

external links for Rix1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome

YOGY DIP


GeneMANIA


YeastRC Mass Spec (Seattle)


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rix1p
1) Gadal O, et al.  (2001) Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol Cell Biol 21(10):3405-15
2) Krogan NJ, et al.  (2004) High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell 13(2):225-39
3) Nissan TA, et al.  (2004) A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol Cell 15(2):295-301
4) Huo L, et al.  (2012) The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle 11(7):1325-39
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41