KOG1/YHR186C Protein Information Help

Standard Name Kog1p
Systematic Name Yhr186cp
Alias Las24p 1
ORF Classification Verified
Description Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors (2, 3, 4, 5)
Name Description Kontroller Of Growth 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,557
Molecular Weight (Da) 177,608
Isoelectric Point (pI) 7.78

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kog1p (InterPro)
Physical Interactions There are 101 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000016834B | P38873
MIPS: YHR186C
NCBI: 122065371 | 458938 | 6321980 | 731756 | NP_012056.1
GenBank/EMBL/DDBJ: DAA06878.1 | U00030
Amino Acid Sequence (or in FASTA format)
 
       1  MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN
      51  GNPIPEEDKQ RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV
     101  MKTHPCARVE AWVDPLNFQD SKKAIEQIGK NLQAQYETLS LRTRYKQSLD
     151  PCVEDVKRFC NSLRRTSKED RILFHYNGHG VPKPTKSGEI WVFNRGYTQY
     201  IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI KDDEEGNHDV
     251  AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF
     301  LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP
     351  LGELNWIFTA ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP
     401  WYNCHPVSDP ELPDSITTHP MWKSWDLAMD EVLTKIVIDL KNAPPATALE
     451  SQMILQQQET LQNGGSSKSN AQDTKAGSIQ TQSRFAVANL STMSLVNNPA
     501  LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW LKYASNVRHP
     551  PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL
     601  LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV
     651  NGMSATNGSA MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL
     701  PFYHSNDTTD EQKAMAVFVL ASFVRNFPLG QKNCFSLELV NKLCFYIDNS
     751  EIPLLRQWCV ILLGLLFADN PLNRFVCMNT GAVEILLKSL KDPVPEVRTA
     801  SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ NQSHLQQQQS
     851  QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL
     901  INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR
     951  NTSDKYSVSQ GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH
    1001  KELGGPFAVM EKFLLKRSSK AHQTGKFGFN SSQVQFVKSS LRSFSPNERV
    1051  DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS LGFSESNSDS DTQSSNTSMK
    1101  SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL NSSFLDYSRE
    1151  YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS
    1201  KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG
    1251  TPFGTKVTDL KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG
    1301  LTDMLLTPRS TGLLTEWLQI RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK
    1351  TSSLITSLTA DQLAGNIFVA GFADGSLRVY DRRLDPRDSM IRRWRAGNDK
    1401  QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES FVDQNVTSQY
    1451  GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT
    1501  STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE
    1551  DERIDYF*

external links for Kog1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Kog1p
1) Araki T, et al.  (2005) LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Genes Genet Syst 80(5):325-43
2) Loewith R, et al.  (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68
3) Jacinto E and Hall MN  (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4(2):117-26
4) Wedaman KP, et al.  (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20
5) Reinke A, et al.  (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62