GND1/YHR183W Protein Information

Standard Name	Gnd1p
Systematic Name	Yhr183wp
ORF Classification	Verified
Description	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication (1, 2, 3, 4)

Experimental Data
Molecules/cell	101000 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	489
Molecular Weight (Da)	53,543
Isoelectric Point (pI)	6.6

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gnd1p (InterPro)
Physical Interactions	There are 44 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000124F5D \| P38720 MIPS: YHR183W NCBI: 157835612 \| 398364913 \| 458910 \| 575391 \| 577839 \| 728743 \| NP_012053.3 \| NM_001179314.3 GenBank/EMBL/DDBJ: DAA06875.1 \| U00028 \| U17155 \| Z46631
External Classifications	EC: 1.1.1.44 [Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)]

Amino Acid Sequence (or in FASTA format)
1 MSADFGLIGL AVMGQNLILN AADHGFTVCA YNRTQSKVDH FLANEAKGKS 51 IIGATSIEDF ISKLKRPRKV MLLVKAGAPV DALINQIVPL LEKGDIIIDG 101 GNSHFPDSNR RYEELKKKGI LFVGSGVSGG EEGARYGPSL MPGGSEEAWP 151 HIKNIFQSIS AKSDGEPCCE WVGPAGAGHY VKMVHNGIEY GDMQLICEAY 201 DIMKRLGGFT DKEISDVFAK WNNGVLDSFL VEITRDILKF DDVDGKPLVE 251 KIMDTAGQKG TGKWTAINAL DLGMPVTLIG EAVFARCLSA LKNERIRASK 301 VLPGPEVPKD AVKDREQFVD DLEQALYASK IISYAQGFML IREAAATYGW 351 KLNNPAIALM WRGGCIIRSV FLGQITKAYR EEPDLENLLF NKFFADAVTK 401 AQSGWRKSIA LATTYGIPTP AFSTALSFYD GYRSERLPAN LLQAQRDYFG 451 AHTFRVLPEC ASDNLPVDKD IHINWTGHGG NVSSSTYQA*

Amino Acid Sequence (or in FASTA format)

       1  MSADFGLIGL AVMGQNLILN AADHGFTVCA YNRTQSKVDH FLANEAKGKS
      51  IIGATSIEDF ISKLKRPRKV MLLVKAGAPV DALINQIVPL LEKGDIIIDG
     101  GNSHFPDSNR RYEELKKKGI LFVGSGVSGG EEGARYGPSL MPGGSEEAWP
     151  HIKNIFQSIS AKSDGEPCCE WVGPAGAGHY VKMVHNGIEY GDMQLICEAY
     201  DIMKRLGGFT DKEISDVFAK WNNGVLDSFL VEITRDILKF DDVDGKPLVE
     251  KIMDTAGQKG TGKWTAINAL DLGMPVTLIG EAVFARCLSA LKNERIRASK
     301  VLPGPEVPKD AVKDREQFVD DLEQALYASK IISYAQGFML IREAAATYGW
     351  KLNNPAIALM WRGGCIIRSV FLGQITKAYR EEPDLENLLF NKFFADAVTK
     401  AQSGWRKSIA LATTYGIPTP AFSTALSFYD GYRSERLPAN LLQAQRDYFG
     451  AHTFRVLPEC ASDNLPVDKD IHINWTGHGG NVSSSTYQA*

external links for Gnd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Gnd1p

1)	Sinha A and Maitra PK (1992) Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae. J Gen Microbiol 138(9):1865-73
2)	Izawa S, et al. (1998) Importance of glucose-6-phosphate dehydrogenase in the adaptive response to hydrogen peroxide in Saccharomyces cerevisiae. Biochem J 330 ( Pt 2)():811-7
3)	Bro C, et al. (2004) Genome-wide transcriptional response of a Saccharomyces cerevisiae strain with an altered redox metabolism. Biotechnol Bioeng 85(3):269-76
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41