STB5/YHR178W Protein Information Help

Standard Name Stb5p
Systematic Name Yhr178wp
ORF Classification Verified
Description Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro (1, 2, 3)
Name Description Sin Three Binding protein
Experimental Data
Molecules/cell 279 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 743
Molecular Weight (Da) 83,472
Isoelectric Point (pI) 8.48

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Stb5p (InterPro)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001360AF | P38699
MIPS: YHR178W
NCBI: 398364891 | 458893 | 731748 | NP_012048.3 | NM_001179309.3
GenBank/EMBL/DDBJ: DAA06871.1 | U00027
Amino Acid Sequence (or in FASTA format)
 
       1  MDGPNFAHQG GRSQRTTELY SCARCRKLKK KCGKQIPTCA NCDKNGAHCS
      51  YPGRAPRRTK KELADAMLRG EYVPVKRNKK VGKSPLSTKS MPNSSSPLSA
     101  NGAITPGFSP YENDDAHKMK QLKPSDPINL VMGASPNSSE GVSSLISVLT
     151  SLNDNSNPSS HLSSNENSMI PSRSLPASVQ QSSTTSSFGG YNTPSPLISS
     201  HVPANAQAVP LQNNNRNTSN GDNGSNVNHD NNNGSTNTPQ LSLTPYANNS
     251  APNGKFDSVP VDASSIEFET MSCCFKGGRT TSWVREDGSF KSIDRSLLDR
     301  FIAAYFKHNH RLFPMIDKIA FLNDAATITD FERLYDNKNY PDSFVFKVYM
     351  IMAIGCTTLQ RAGMVSQDEE CLSEHLAFLA MKKFRSVIIL QDIETVRCLL
     401  LLGIYSFFEP KGSSSWTISG IIMRLTIGLG LNRELTAKKL KSMSALEAEA
     451  RYRVFWSAYC FERLVCTSLG RISGIDDEDI TVPLPRALYV DERDDLEMTK
     501  LMISLRKMGG RIYKQVHSVS AGRQKLTIEQ KQEIISGLRK ELDEIYSRES
     551  ERRKLKKSQM DQVERENNST TNVISFHSSE IWLAMRYSQL QILLYRPSAL
     601  MPKPPIDSLS TLGEFCLQAW KHTYTLYKKR LLPLNWITLF RTLTICNTIL
     651  YCLCQWSIDL IESKIEIQQC VEILRHFGER WIFAMRCADV FQNISNTILD
     701  ISLSHGKVPN MDQLTRELFG ASDSYQDILD ENNVDVSWVD KLV*

external links for Stb5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Stb5p
1) Kasten MM and Stillman DJ  (1997) Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. Mol Gen Genet 256(4):376-86
2) Akache B, et al.  (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60
3) Larochelle M, et al.  (2006) Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol 26(17):6690-701
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41