ATG7/YHR171W Protein Information Help

Standard Name Atg7p 1
Systematic Name Yhr171wp
Alias Cvt2p 2 , Apg7p 3 , Apg11p 3
ORF Classification Verified
Description Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation (3, 4, 5, 6)
Name Description AuTophaGy related 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 630
Molecular Weight (Da) 71,427
Isoelectric Point (pI) 6.22

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Atg7p (InterPro)
Physical Interactions There are 43 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000125C64 | P38862
MIPS: YHR171W
NCBI: 347447827 | 347447828 | 347447829 | 347447831 | 357380316 | 358009561 | 358009563 | 358009649 | 358009650 | 358009651 | 358009652 | 358009655 | 358009656 | 3688625 | 414145773 | 414145774 | 414145775 | 414145778 | 414145779 | 458899 | 6321965 | 731742 | NP_012041.1
GenBank/EMBL/DDBJ: DAA06864.1 | AB017925 | U00027
Amino Acid Sequence (or in FASTA format)
 
       1  MSSERVLSYA PAFKSFLDTS FFQELSRLKL DVLKLDSTCQ PLTVNLDLHN
      51  IPKSADQVPL FLTNRSFEKH NNKRTNEVPL QGSIFNFNVL DEFKNLDKQL
     101  FLHQRALECW EDGIKDINKC VSFVIISFAD LKKYRFYYWL GVPCFQRPSS
     151  TVLHVRPEPS LKGLFSKCQK WFDVNYSKWV CILDADDEIV NYDKCIIRKT
     201  KVLAIRDTST MENVPSALTK NFLSVLQYDV PDLIDFKLLI IRQNEGSFAL
     251  NATFASIDPQ SSSSNPDMKV SGWERNVQGK LAPRVVDLSS LLDPLKIADQ
     301  SVDLNLKLMK WRILPDLNLD IIKNTKVLLL GAGTLGCYVS RALIAWGVRK
     351  ITFVDNGTVS YSNPVRQALY NFEDCGKPKA ELAAASLKRI FPLMDATGVK
     401  LSIPMIGHKL VNEEAQHKDF DRLRALIKEH DIIFLLVDSR ESRWLPSLLS
     451  NIENKTVINA ALGFDSYLVM RHGNRDEQSS KQLGCYFCHD VVAPTDSLTD
     501  RTLDQMCTVT RPGVAMMASS LAVELMTSLL QTKYSGSETT VLGDIPHQIR
     551  GFLHNFSILK LETPAYEHCP ACSPKVIEAF TDLGWEFVKK ALEHPLYLEE
     601  ISGLSVIKQE VERLGNDVFE WEDDESDEIA *

external links for Atg7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Atg7p
1) Klionsky DJ, et al.  (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2) Harding TM, et al.  (1995) Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J Cell Biol 131(3):591-602
3) Tsukada M and Ohsumi Y  (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
4) Mizushima N, et al.  (1998) A protein conjugation system essential for autophagy. Nature 395(6700):395-8
5) Ichimura Y, et al.  (2000) A ubiquitin-like system mediates protein lipidation. Nature 408(6811):488-92
6) Ichimura Y, et al.  (2004) In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem 279(39):40584-92