MTG2/YHR168W Protein Information

Standard Name	Mtg2p 1
Systematic Name	Yhr168wp
ORF Classification	Verified
Description	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly (1)
Name Description	MiTochondrial Gtpase 2 1

Experimental Data
Molecules/cell	189 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	518
Molecular Weight (Da)	57,847
Isoelectric Point (pI)	9.55

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mtg2p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00003B9FFA \| P38860 MIPS: YHR168W NCBI: 115502420 \| 330443587 \| 458902 \| 49354655 \| 731739 \| NP_012038.2 GenBank/EMBL/DDBJ: DAA06861.2 \| AY643812 \| U00027

Amino Acid Sequence (or in FASTA format)
1 MSIAWSSVFK RELRLERFLP RVYSTKVPDN APRAADNEQW LETLRPITHP 51 EQKKSDHDVS YTRHINVPLG EVTSVNYLQR YNKHKHSQGN FVDVRIVKCK 101 SGAGGSGAVS FFRDAGRSIG PPDGGDGGAG GSVYIQAVAG LGSLAKMKTT 151 YTAEDGEAGA ARQLDGMRGR DVLIQVPVGT VVKWCLPPQK VRELVEREMR 201 KDNNATLRSI LGSTAVNLSV SSGSHRKKIQ LYRHEMAESW LFKDKAKEYH 251 ENKDWFKDLH KKMEAYDHSL EQSELFNDQF PLAGLDLNQP MTKPVCLLKG 301 GQGGLGNMHF LTNLIRNPRF SKPGRNGLEQ HFLFELKSIA DLGLIGLPNA 351 GKSTILNKIS NAKPKIGHWQ FTTLSPTIGT VSLGFGQDVF TVADIPGIIQ 401 GASLDKGMGL EFLRHIERSN GWVFVLDLSN KNPLNDLQLL IEEVGTLEKV 451 KTKNILIVCN KVDIDAEKSE SFAKYLQVEK FSKSQEWDCV PISALREENI 501 DVLKKKMFKC ARQSEFDK*

Amino Acid Sequence (or in FASTA format)

       1  MSIAWSSVFK RELRLERFLP RVYSTKVPDN APRAADNEQW LETLRPITHP
      51  EQKKSDHDVS YTRHINVPLG EVTSVNYLQR YNKHKHSQGN FVDVRIVKCK
     101  SGAGGSGAVS FFRDAGRSIG PPDGGDGGAG GSVYIQAVAG LGSLAKMKTT
     151  YTAEDGEAGA ARQLDGMRGR DVLIQVPVGT VVKWCLPPQK VRELVEREMR
     201  KDNNATLRSI LGSTAVNLSV SSGSHRKKIQ LYRHEMAESW LFKDKAKEYH
     251  ENKDWFKDLH KKMEAYDHSL EQSELFNDQF PLAGLDLNQP MTKPVCLLKG
     301  GQGGLGNMHF LTNLIRNPRF SKPGRNGLEQ HFLFELKSIA DLGLIGLPNA
     351  GKSTILNKIS NAKPKIGHWQ FTTLSPTIGT VSLGFGQDVF TVADIPGIIQ
     401  GASLDKGMGL EFLRHIERSN GWVFVLDLSN KNPLNDLQLL IEEVGTLEKV
     451  KTKNILIVCN KVDIDAEKSE SFAKYLQVEK FSKSQEWDCV PISALREENI
     501  DVLKKKMFKC ARQSEFDK*

external links for Mtg2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mtg2p

1)	Datta K, et al. (2005) The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Mol Biol Cell 16(2):954-63
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41