PEX18/YHR160C Protein Information

Standard Name	Pex18p 1
Systematic Name	Yhr160cp
ORF Classification	Verified
Description	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; PEX18 has a paralog, PEX21, that arose from the whole genome duplication (1, 2, 3)
Name Description	PEroXin 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	283
Molecular Weight (Da)	32,037
Isoelectric Point (pI)	4.78

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pex18p (InterPro)
Physical Interactions	There are 24 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B2E9 \| P38855 MIPS: YHR160C NCBI: 500666 \| 6321954 \| 731734 \| NP_012030.1 GenBank/EMBL/DDBJ: DAA06853.1 \| U10397

Amino Acid Sequence (or in FASTA format)
1 MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE 51 LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN 101 FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ 151 IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE 201 TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN 251 GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA*

Amino Acid Sequence (or in FASTA format)

       1  MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE
      51  LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN
     101  FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ
     151  IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE
     201  TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN
     251  GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA*

external links for Pex18p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pex18p

1)	Purdue PE, et al. (1998) Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol 143(7):1859-69
2)	Stein K, et al. (2002) Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Mol Cell Biol 22(17):6056-69
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61