CHS7/YHR142W Protein Information

Standard Name	Chs7p
Systematic Name	Yhr142wp
ORF Classification	Verified
Description	Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress (1, 2)
Name Description	CHitin Synthase-related 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	316
Molecular Weight (Da)	34,898
Isoelectric Point (pI)	5.62

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Chs7p (InterPro)
Transmembrane Domains	There are 7 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 27 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B2D9 \| P38843 MIPS: YHR142W NCBI: 500657 \| 51013407 \| 6321935 \| 731723 \| NP_012011.1 GenBank/EMBL/DDBJ: DAA06835.1 \| AY692978 \| U10397

Amino Acid Sequence (or in FASTA format)
1 MAFSDFAAIC SKTPLPLCSV IKSKTHLILS NSTIIHDFDP LNLNVGVLPR 51 CYARSIDLAN TVIFDVGNAF INIGALGVIL IILYNIRQKY TAIGRSEYLY 101 FFQLTLLLII FTLVVDCGVS PPGSGSYPYF VAIQIGLAGA CCWALLIIGF 151 LGFNLWEDGT TKSMLLVRGT SMLGFIANFL ASILTFKAWI TDHKVATMNA 201 SGMIVVVYII NAIFLFVFVI CQLLVSLLVV RNLWVTGAIF LGLFFFVAGQ 251 VLVYAFSTQI CEGFKHYLDG LFFGSICNVF TLMMVYKTWD MTTDDDLEFG 301 VSVSKDGDVV YDNGFM*

Amino Acid Sequence (or in FASTA format)

       1  MAFSDFAAIC SKTPLPLCSV IKSKTHLILS NSTIIHDFDP LNLNVGVLPR
      51  CYARSIDLAN TVIFDVGNAF INIGALGVIL IILYNIRQKY TAIGRSEYLY
     101  FFQLTLLLII FTLVVDCGVS PPGSGSYPYF VAIQIGLAGA CCWALLIIGF
     151  LGFNLWEDGT TKSMLLVRGT SMLGFIANFL ASILTFKAWI TDHKVATMNA
     201  SGMIVVVYII NAIFLFVFVI CQLLVSLLVV RNLWVTGAIF LGLFFFVAGQ
     251  VLVYAFSTQI CEGFKHYLDG LFFGSICNVF TLMMVYKTWD MTTDDDLEFG
     301  VSVSKDGDVV YDNGFM*

external links for Chs7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Chs7p

1)	Trilla JA, et al. (1999) Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. J Cell Biol 145(6):1153-63
2)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76